Näslund Olivia, Jakobsson Stina, Thurin Erik, Skoglund Thomas, Pettersson-Segerlind Jenny, Brynedal Boel, Jakola Asgeir S, Bartek Jiri
Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Department of Surgery, Östra/Sahlgrenska University Hospital, Gothenburg, Sweden.
Neurooncol Pract. 2024 Nov 15;11(6):723-732. doi: 10.1093/nop/npae047. eCollection 2024 Dec.
Asymptomatic patients with meningiomas are increasingly detected, where management can be challenging in terms of surgery versus watchful waiting. Health-related quality of life (HRQoL) is an important factor in clinical decision-making, albeit not greatly studied in this patient group. The aim of this paper is to map the HRQoL among patients with surgically removed asymptomatic meningioma as compared to the general population.
Patients with first-time surgically treated asymptomatic meningioma between 2007 and 2013 were identified. Patients were invited in 2017 to answer a survey regarding different aspects of quality of life, using EuroQoL (EQ)-5D-3L, perceived health, lifestyle, and occupancy. Data from electronic patient records was obtained. The patients were matched based on age and gender with data from the Stockholm Region Public Health Cohort database.
There was no difference in EQ-5D-3L or visual analog scale between the patients and their matched controls. Patients and controls experienced ill health to the same extent, but patients felt to a greater extent that this impacted their way of life. In 36% of patients, preoperative occupation was not resumed, mostly due to cognitive symptoms. Additionally, the study suggested social detachment in this cohort, as significantly more patients were living alone and had less emotional support compared to controls.
Although surgically treated patients with asymptomatic intracranial meningioma have similar overall HRQoL compared to the general population, surgery has an impact on return to work and cognitive function.
无症状脑膜瘤患者的检出率日益增加，在手术治疗与观察等待的管理决策方面可能具有挑战性。健康相关生活质量（HRQoL）是临床决策中的一个重要因素，尽管在该患者群体中对此研究较少。本文旨在描绘与普通人群相比，接受手术切除的无症状脑膜瘤患者的健康相关生活质量。
确定2007年至2013年间首次接受手术治疗的无症状脑膜瘤患者。2017年邀请患者回答一项关于生活质量不同方面的调查，采用欧洲五维健康量表（EQ）-5D-3L、感知健康、生活方式和职业状况。获取电子病历数据。根据年龄和性别将患者与斯德哥尔摩地区公共卫生队列数据库的数据进行匹配。
患者与其匹配的对照组在EQ-5D-3L或视觉模拟量表上无差异。患者和对照组的健康状况不佳程度相同，但患者更强烈地感觉到这影响了他们的生活方式。36%的患者术前职业未能恢复，主要原因是认知症状。此外，该研究表明该队列存在社会脱离现象，因为与对照组相比，独居且获得情感支持较少的患者明显更多。
尽管接受手术治疗的无症状颅内脑膜瘤患者与普通人群的总体健康相关生活质量相似，但手术对重返工作和认知功能有影响。
