生活方式干预可改善肥厚型心肌病患者的副交感神经活动。
Lifestyle Intervention Improves Parasympathetic Activity in Hypertrophic Cardiomyopathy.
作者信息
Alyahya Alaa I, Charman Sarah J, Okwose Nduka C, Fuller Amy S, Eggett Christopher, Luke Peter, Bailey Kristian, MacGowan Guy A, Jakovljevic Djordje G
机构信息
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, UK (AIA, SJC, NCO, ASF, CE, PL, DGJ).
Cardiology Department, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK (AIA, SJC, NCO, ASF, CE, PL, KB, GAM, DGJ).
出版信息
Am J Lifestyle Med. 2024 May 16:15598276241253187. doi: 10.1177/15598276241253187.
UNLABELLED
Background A limited number of studies have investigated the effects of lifestyle interventions in hypertrophic cardiomyopathy (HCM). This study evaluated the effect of a novel lifestyle intervention incorporating physical activity (PA) and dietary nitrate supplementation on heart rate variability (HRV) and haemodynamic measures in HCM.
METHODS
Twenty-eight individuals with HCM were randomised into either the intervention or control group. Frequency-domain HRV measures including low frequency power (LF), high frequency power (HF) and LF/HF were recorded at rest using bioimpedance. Non-invasive haemodynamic variables were recorded at rest using bioreactance. Participants in the intervention group consumed 6 mmol of nitrate daily (concentrated beetroot juice) and were instructed to increase and maintain daily PA by ≥ 2000 steps/day above baseline for 16 weeks. Control group participants retained their usual lifestyle and monitored daily step counts.
RESULTS
There was a significant increase in post-intervention HF power (7.54 ± 2.14 vs 8.78 ± 1.60 ms, < .01) and LF power (6.89 ± 2.33 vs 8.17 ± 1.55, < .01) in the intervention but not in the control group. Resting mean arterial blood pressure (MABP) in the intervention group significantly reduced at follow-up (108 ± 6 vs 102 ± 7 mmHg, < .01).
CONCLUSIONS
A novel lifestyle intervention including PA and dietary nitrate supplementation enhanced parasympathetic activity and resting MABP in HCM.
未标注
背景 仅有少数研究调查了生活方式干预对肥厚型心肌病（HCM）的影响。本研究评估了一种结合体育活动（PA）和膳食硝酸盐补充的新型生活方式干预对HCM患者心率变异性（HRV）和血流动力学指标的影响。
方法
28名HCM患者被随机分为干预组或对照组。使用生物阻抗在静息状态下记录频域HRV指标，包括低频功率（LF）、高频功率（HF）和LF/HF。使用生物反应技术在静息状态下记录无创血流动力学变量。干预组参与者每天摄入6 mmol硝酸盐（浓缩甜菜根汁），并被指示将每日PA增加并维持在比基线水平高≥2000步/天，持续16周。对照组参与者保持其通常的生活方式并监测每日步数。
结果
干预组干预后HF功率显著增加（7.54±2.14对8.78±1.60 ms，P<.01）和LF功率显著增加（6.89±2.33对8.17±1.55，P<.01），而对照组未出现这种情况。干预组随访时静息平均动脉血压（MABP）显著降低（108±6对102±7 mmHg，P<.01）。
结论
一种包括PA和膳食硝酸盐补充的新型生活方式干预增强了HCM患者的副交感神经活动和静息MABP。
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