Iweala Onyinye I
Department of Medicine, Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology and Department of Pediatrics, Food Allergy Initiative, Division of Allergy and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Ann Intern Med Clin Cases. 2023 Jun;2(6). doi: 10.7326/aimcc.2023.0578. Epub 2023 Jun 20.
-Gal syndrome, also known as red or mammalian meat allergy, results from immunoglobulin E-mediated hypersensitivity responses to the carbohydrate galactose--1,3-galactose (-gal). Patients with -gal syndrome experience immediate onset of allergic symptoms following the injection of pharmaceutical products containing -gal. However, it typically takes 2 hours or more after dietary -gal ingestion before patients with -gal syndrome experience immunoglobulin E-mediated hypersensitivity responses. The case report by Heffes-Doon and colleagues highlights the lack of official guidelines on when and how to reintroduce mammalian meat products into the diet when there is clear laboratory evidence of declining -gal immunoglobulin E levels.
α-半乳糖综合征，也称为红肉或哺乳动物肉过敏，是由免疫球蛋白E介导的对半乳糖-α-1,3-半乳糖（α-Gal）碳水化合物的超敏反应引起的。α-半乳糖综合征患者在注射含有α-Gal的药品后会立即出现过敏症状。然而，α-半乳糖综合征患者在摄入饮食中的α-Gal后，通常需要2小时或更长时间才会出现免疫球蛋白E介导的超敏反应。赫夫斯-杜恩及其同事的病例报告强调，当有明确的实验室证据表明α-Gal免疫球蛋白E水平下降时，缺乏关于何时以及如何将哺乳动物肉类产品重新引入饮食的官方指南。
