Kim Sang-Yoon, Lim Woochang
Institute for Computational Neuroscience and Department of Science Education, Daegu National University of Education, Daegu, 42411 Korea.
Cogn Neurodyn. 2024 Oct;18(5):2311-2321. doi: 10.1007/s11571-024-10089-x. Epub 2024 Mar 12.
We are concerned about sparsely synchronized rhythms (SSRs), associated with diverse cognitive functions, in the hippocampal dentate gyrus. Distinctly, adult-born immature GCs (imGCs) emerge through neurogenesis, in addition to the mature granule cells (mGCs) (emerged in the developmental stage). In prior work, these mGCs and imGCs were found to exhibit their distinct roles in pattern separation and integration for encoding cortical inputs, respectively. But, the underlying dynamical mechanismremains unclear. In this paper, we first study influence of the young adult-born imGCs on emergence of SSRs in the populations of the mGCs and the imGCs; population and individual firing behaviors in the SSRs are intensively studied. We then examine how the SSRs play a role in the underlying mechanism for pattern separation and integration. Particularly, quantitative relationship between SSRs of the mGCs and the imGCs and their pattern separation and integration is investigated.
The online version contains supplementary material available at 10.1007/s11571-024-10089-x.
我们关注海马齿状回中与多种认知功能相关的稀疏同步节律（SSRs）。值得注意的是，除了（在发育阶段出现的）成熟颗粒细胞（mGCs）外，成年新生的未成熟颗粒细胞（imGCs）通过神经发生而出现。在先前的研究中，发现这些mGCs和imGCs分别在编码皮质输入的模式分离和整合中发挥着不同的作用。但是，其潜在的动力学机制仍不清楚。在本文中，我们首先研究成年新生的imGCs对mGCs和imGCs群体中SSRs出现的影响；深入研究了SSRs中的群体和个体放电行为。然后，我们研究SSRs如何在模式分离和整合的潜在机制中发挥作用。特别地，研究了mGCs和imGCs的SSRs与其模式分离和整合之间的定量关系。
在线版本包含可在10.1007/s11571-024-10089-x获取的补充材料。
