Hirose M, Hagiwara A, Masui T, Inoue K, Ito N
Cancer Lett. 1986 Feb;30(2):169-74. doi: 10.1016/0304-3835(86)90085-6.
The possibility that changes in the forestomach of rats induced by butylated hydroxyanisole (BHA) are caused by inductions of free radicals and their reactions with macromolecules was examined. Groups of five male F344 rats were pretreated with 1% alpha-tocopherol, 1% ellagic acid, 1% propyl gallate, 0.25% ethoxyquin, 0.5% glutathione, 1% sodium L-ascorbate or 1% 3,3'-thiodipropionic acid for 1 week, then treated with the same antioxidant plus 1% BHA for 1 week, and then killed. Histological examination showed that BHA induced epithelial hyperplasia of the forestomach. This induction of hyperplasia was not inhibited, but increased by the antioxidants, particularly propyl gallate and ethoxyquin. Thus the induction of hyperplasia by BHA may not be related to a free radical reaction.
研究了丁基羟基茴香醚（BHA）诱导的大鼠前胃变化是否由自由基的诱导及其与大分子的反应引起。将五组雄性F344大鼠分别用1%α-生育酚、1%鞣花酸、1%没食子酸丙酯、0.25%乙氧喹、0.5%谷胱甘肽、1%L-抗坏血酸钠或1%3,3'-硫代二丙酸预处理1周，然后用相同的抗氧化剂加1%BHA处理1周，随后处死。组织学检查显示，BHA诱导了前胃上皮增生。抗氧化剂并未抑制这种增生诱导，反而使其增加，尤其是没食子酸丙酯和乙氧喹。因此，BHA诱导的增生可能与自由基反应无关。
