Fukushima S, Sakata T, Tagawa Y, Shibata M A, Hirose M, Ito N
Cancer Res. 1987 Apr 15;47(8):2113-6.
The modifying effects of antioxidants were examined in a carcinogenesis system after N,N-dibutylnitrosamine treatment. Male F344 rats were given 0.05% N,N-dibutylnitrosamine in their drinking water for 4 wk and then treated with basal diet containing 2% butylated hydroxyanisole (BHA), 1% butylated hydroxytoluene (BHT) with 7 ppm vitamin K, 0.8% ethoxyquin, 5% sodium L-ascorbate, 5% sodium erythorbate, or no added chemical for 32 wk. BHA enhanced forestomach carcinogenesis but did not enhance esophageal carcinogenesis. BHT enhanced esophageal carcinogenesis but did not enhance forestomach carcinogenesis. Ethoxyquin significantly enhanced esophageal tumorigenesis. Neither esophageal nor forestomach carcinogenesis was affected by the other antioxidants evaluated. BHA significantly increased DNA synthesis of the forestomach epithelium, whereas BHT tended to increase that of the esophageal epithelium. Thus, BHA and BHT showed different modifying responses in carcinogenesis of the esophagus and forestomach.
在N，N - 二丁基亚硝胺处理后的致癌系统中研究了抗氧化剂的修饰作用。给雄性F344大鼠饮用含0.05% N，N - 二丁基亚硝胺的水4周，然后用含2%丁基化羟基茴香醚（BHA）、1%丁基化羟基甲苯（BHT）与7 ppm维生素K、0.8%乙氧喹、5% L - 抗坏血酸钠、5%异抗坏血酸钠的基础饲料或不添加化学物质的基础饲料处理32周。BHA增强了前胃致癌作用，但未增强食管癌发生。BHT增强了食管癌发生，但未增强前胃致癌作用。乙氧喹显著增强了食管肿瘤发生。所评估的其他抗氧化剂均未影响食管癌和前胃癌发生。BHA显著增加了前胃上皮的DNA合成，而BHT则倾向于增加食管上皮的DNA合成。因此，BHA和BHT在食管和前胃的致癌作用中表现出不同的修饰反应。
