Wang Xinpeng, He Yingying, Wu Yudong, Qi Zhongshi, Wang Yongliang, Ding Junhang, Zhang Jie, Fan Yubo, Wang Hongzhang
Qingdao Central Hospital, School of Rehabilitation Sciences and Engineering, School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266113, China.
Qingdao Key Laboratory of Marine Natural Products R&D Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China.
iScience. 2024 Oct 16;27(11):111183. doi: 10.1016/j.isci.2024.111183. eCollection 2024 Nov 15.
Excellent biocompatibility of liquid metals is the basis for developing biomedical applications, such as implantable devices, drug delivery, and tumor therapy. Especially, a systematic study to reveal the influence of gallium-based liquid metals on the composition of blood while they are used in the human body is vital but missing. Here, the compatibility of three kinds of frequently used gallium-based liquid metals with human blood and serum was explored systematically. The results show that treating blood and serum with gallium-based liquid metals did not cause hemolysis, suggesting red blood cells are not damaged or ruptured, and treatment had a negligible effect on the components in the blood. Additionally, the serum levels of glucose, cholesterol, and liver function molecules showed no change after adding liquid metals. These findings suggest that liquid metals have high compatibility with human blood and serum and are conductive to be applied in the fields of biomedical engineering.
液态金属优异的生物相容性是开发生物医学应用（如可植入设备、药物递送和肿瘤治疗）的基础。特别是，在人体使用镓基液态金属时，开展一项系统研究以揭示其对血液成分的影响至关重要，但目前仍缺失此类研究。在此，我们系统地探究了三种常用镓基液态金属与人体血液和血清的相容性。结果表明，用镓基液态金属处理血液和血清不会导致溶血，这表明红细胞未受损或破裂，且处理对血液中的成分影响可忽略不计。此外，添加液态金属后，血糖、胆固醇和肝功能分子的血清水平未发生变化。这些发现表明，液态金属与人体血液和血清具有高度相容性，有利于在生物医学工程领域应用。
