Simonato L, Fletcher A C, Cherrie J, Andersen A, Bertazzi P A, Charney N, Claude J, Dodgson J, Esteve J, Frentzel-Beyme R
Cancer Lett. 1986 Feb;30(2):189-200. doi: 10.1016/0304-3835(86)90088-1.
A historical cohort of 21,967 workers ever employed in 13 European factories manufacturing various types of man-made mineral fibres (MMMF) was observed until 1982. Overall there were 2719 deaths (standardised mortality ratio (SMR) = 111) of which 189 were from lung cancer (SMR = 125). For the glasswool and rockwool/slagwool production subcohorts the lung cancer SMRs rose with time since first exposure, exceeding 170 for the period of 30 or more years. Adjustment for regional variations in mortality substantially reduced the excess in the glasswool group, but not in the rockwool/slagwool. In neither subgroup was there any relationship of lung cancer mortality with length of employment. During the early years of rockwool/slagwool production there was the potential for much higher fibrous dust exposure than at present, because of the absence of dust suppressing oil and/or the use of a batch production process. In addition slag was widely used as a raw material. Amongst workers employed during the early phase, there were 10 lung cancer deaths giving SMRs of 270 and 244 for the periods 20-29 and 30 or more years since first exposure. This group accounts for most of the absolute excess of lung cancer for the rockwool/slagwool plants.
对曾在13家欧洲工厂工作、生产各类人造矿物纤维（MMMF）的21967名工人组成的历史性队列进行观察，直至1982年。总体上有2719人死亡（标准化死亡比（SMR）=111），其中189人死于肺癌（SMR = 125）。对于玻璃棉和岩棉/矿渣棉生产亚队列，肺癌SMR自首次接触后随时间上升，在接触30年及以上时超过170。对死亡率的区域差异进行调整后，玻璃棉组的超额死亡率大幅降低，但岩棉/矿渣棉组未降低。在这两个亚组中，肺癌死亡率与工作时长均无关联。在岩棉/矿渣棉生产的早期，由于缺乏抑尘油和/或采用间歇生产工艺，纤维粉尘暴露量可能比目前高得多。此外，矿渣被广泛用作原材料。在早期阶段受雇的工人中，有10人死于肺癌，自首次接触后20 - 29年和30年及以上时间段的SMR分别为270和244。该组占岩棉/矿渣棉工厂肺癌绝对超额死亡数的大部分。
