Boffetta P, Saracci R, Andersen A, Bertazzi P A, Chang-Claude J, Cherrie J, Ferro G, Frentzel-Beyme R, Hansen J, Olsen J, Plato N, Teppo L, Westerholm P, Winter P D, Zocchetti C
International Agency for Research on Cancer, Lyon, France.
Epidemiology. 1997 May;8(3):259-68. doi: 10.1097/00001648-199705000-00006.
We have updated the follow-up of cancer mortality for a cohort study of man-made vitreous fiber production workers from Denmark, Finland, Norway, Sweden, United Kingdom, Germany, and Italy, from 1982 to 1990. In the mortality analysis, 22,002 production workers contributed 489,551 person-years, during which there were 4,521 deaths. Workers with less than 1 year of employment had an increased mortality [standardized mortality ratio (SMR) = 1.45; 95% confidence interval (CI) = 1.37-1.53]. Workers with 1 year or more of employment, contributing 65% of person-years, had an SMR of 1.05 (95% CI = 1.02-1.09). The SMR for lung cancer was 1.34 (95% CI = 1.08-1.63, 97 deaths) among rock/slag wool workers and 1.27 (95% CI = 1.07-1.50, 140 deaths) among glass wool workers. In the latter group, no increase was present when local mortality rates were used. Among rock/slag wool workers, the risk of lung cancer increased with time-since-first-employment and duration of employment. The trend in lung cancer mortality according to technologic phase at first employment was less marked than in the previous follow-up. We obtained similar results from a Poisson regression analysis limited to rock/slag wool workers. Five deaths from pleural mesothelioma were reported, which may not represent an excess. There was no apparent excess for other categories of neoplasm. Tobacco smoking and other factors linked to social class, as well as exposures in other industries, appear unlikely to explain the whole increase in lung cancer mortality among rock/slag wool workers. Limited data on other agents do not indicate an important role of asbestos, slag, or bitumen. These results are not sufficient to conclude that the increased lung cancer risk is the result of exposure to rock/slag wool; however, insofar as respirable fibers were an important component of the ambient pollution of the working environment, they may have contributed to the increased risk.
我们更新了对丹麦、芬兰、挪威、瑞典、英国、德国和意大利的人造玻璃纤维生产工人队列研究中癌症死亡率的随访情况，随访时间为1982年至1990年。在死亡率分析中，22,002名生产工人贡献了489,551人年，在此期间有4,521人死亡。工作年限不足1年的工人死亡率有所增加[标准化死亡率比（SMR）=1.45；95%置信区间（CI）=1.37 - 1.53]。工作年限为1年或更长时间的工人贡献了65%的人年，其SMR为1.05（95%CI = 1.02 - 1.09）。岩棉/矿渣棉工人中肺癌的SMR为1.34（95%CI = 1.08 - 1.63，97例死亡），玻璃棉工人中肺癌的SMR为1.27（95%CI = 1.07 - 1.50，140例死亡）。在玻璃棉工人组中，使用当地死亡率时未发现死亡率增加。在岩棉/矿渣棉工人中，肺癌风险随首次就业后的时间和就业时长增加。根据首次就业时的技术阶段划分的肺癌死亡率趋势不如前次随访明显。我们通过仅限于岩棉/矿渣棉工人的泊松回归分析获得了类似结果。报告了5例胸膜间皮瘤死亡病例，这可能并不代表超额死亡。其他肿瘤类别未出现明显超额死亡。吸烟和与社会阶层相关的其他因素，以及其他行业的暴露情况，似乎无法解释岩棉/矿渣棉工人肺癌死亡率的全部增加情况。关于其他因素的有限数据并未表明石棉、矿渣或沥青起重要作用。这些结果不足以得出肺癌风险增加是接触岩棉/矿渣棉所致的结论；然而，鉴于可吸入纤维是工作环境空气污染的重要组成部分，它们可能导致了风险增加。
