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HIV感染者感染的转录谱

Transcriptional profile of infection in people living with HIV.

作者信息

Tepekule Burcu, Jörimann Lisa, Schenkel Corinne D, Opitz Lennart, Tschumi Jasmin, Wolfensberger Rebekka, Neumann Kathrin, Kusejko Katharina, Zeeb Marius, Boeck Lucas, Kälin Marisa, Notter Julia, Furrer Hansjakob, Hoffmann Matthias, Hirsch Hans H, Calmy Alexandra, Cavassini Matthias, Labhardt Niklaus D, Bernasconi Enos, Oesch Gabriela, Metzner Karin J, Braun Dominique L, Günthard Huldrych F, Kouyos Roger D, Duffy Fergal, Nemeth Johannes

机构信息

Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.

Institute of Medical Virology, University of Zurich, Zurich, Switzerland.

出版信息

iScience. 2024 Oct 21;27(11):111228. doi: 10.1016/j.isci.2024.111228. eCollection 2024 Nov 15.

DOI:10.1016/j.isci.2024.111228
PMID:39555417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11565417/
Abstract

In people with HIV-1 (PWH), (MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct clustering in MTB-infected individuals. Functional annotation identified alterations in IL-6, TNF, and KRAS pathways. Notably, MTB-related genes displayed an inverse correlation with HIV-1 viremia, at both individual and signature score levels. These findings suggest that MTB infection in PWH induces a shift in immune system activation, inversely related to HIV-1 viral load. These results may explain the observed enhanced antiretroviral control in MTB-infected PWH. This study highlights the complex interplay between MTB and HIV-1, emphasizing the importance of understanding their interaction for managing co-infections in this population.

摘要

在人类免疫缺陷病毒1型感染者（PWH）中，结核分枝杆菌（MTB）感染构成重大威胁。虽然活动性肺结核（TB）会加速免疫缺陷，但无症状期MTB与HIV-1之间的相互作用仍不清楚。对病毒载量得到控制和未得到控制的PWH外周血单核细胞（PBMC）转录组谱进行分析，结果显示MTB感染个体存在明显的聚类。功能注释确定了白细胞介素-6、肿瘤坏死因子和KRAS信号通路的改变。值得注意的是，MTB相关基因在个体水平和特征评分水平上均与HIV-1病毒血症呈负相关。这些发现表明，PWH中的MTB感染会导致免疫系统激活发生转变，与HIV-1病毒载量呈负相关。这些结果可能解释了在MTB感染的PWH中观察到的抗逆转录病毒控制增强的现象。本研究突出了MTB与HIV-1之间复杂的相互作用，强调了了解它们的相互作用对于管理该人群合并感染的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/55f03a5e2fda/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/0cce5ea94c7a/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/e44f60c328f5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/aa6757173420/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/4a1a8aa72db1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/55f03a5e2fda/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/0cce5ea94c7a/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/e44f60c328f5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/aa6757173420/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/4a1a8aa72db1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af28/11565417/55f03a5e2fda/gr4.jpg

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