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在英国一家急症医院对40毫克辛伐他汀的某些相互作用进行的回顾性观察研究。

A retrospective observational study of certain interactions with simvastatin 40 mg in an acute hospital in England.

作者信息

Boamah Danita, Bastian Liam, Wilcock Michael

机构信息

Trainee Pharmacist.

Lead Pharmacist for Digital Medicines.

出版信息

Br J Cardiol. 2024 May 14;31(2):020. doi: 10.5837/bjc.2024.020. eCollection 2024.

DOI:10.5837/bjc.2024.020
PMID:39555459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11562568/
Abstract

The use of simvastatin 40 mg with various interacting medicines may lead to an increased risk of myopathy. We examined the extent to which hospital inpatients were prescribed simvastatin 40 mg with amiodarone, amlodipine, diltiazem, or verapamil, and assessed if any action was taken by prescribers or the pharmacy team to avoid this interaction. We found 56 patients on a combination of interest during their stay. Of the 20 (36%) patients not discharged on the combination, in six instances this was due to pharmacy intervention, while the remaining instances when simvastatin 40 mg or the interacting drug was amended or ceased were due to other clinical reasons. There is a need among clinicians and pharmacy teams within the hospital for recognition and management of these particular interactions.

摘要

辛伐他汀40毫克与多种相互作用药物联合使用可能会增加患肌病的风险。我们调查了住院患者中使用辛伐他汀40毫克与胺碘酮、氨氯地平、地尔硫䓬或维拉帕米联合用药的情况，并评估了开处方者或药房团队是否采取了任何措施来避免这种相互作用。我们发现有56名患者在住院期间使用了相关联合用药。在20名（36%）未以联合用药方式出院的患者中，有6例是由于药房干预，而其余辛伐他汀40毫克或相互作用药物被调整或停用的情况则是由于其他临床原因。医院的临床医生和药房团队需要认识并处理这些特定的相互作用。