Song Hongyun, Zhu Sunan, Pan Zongyou, Yu XiaoJing, Xiong Bing, Dai Xuesong
Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, China.
Front Hum Neurosci. 2024 Nov 1;18:1457823. doi: 10.3389/fnhum.2024.1457823. eCollection 2024.
This study aimed to characterize the differences in neural function among patients with different functional abilities 2 years after anterior cruciate ligament reconstruction (ACLR).
Resting-state functional magnetic resonance imaging was performed to obtain blood-oxygen-level-dependent values for ACLR returned to sports coper participants (CP), non-coper participants (NP), and healthy controls (HC). The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) calculated changes in the standard frequency band (SFB) (0.01-0.08 Hz), Slow4 (0.027-0.073 Hz), and Slow5 (0.01-0.027 Hz). Clinical correlations were investigated.
The right cerebellum_8 and bilateral putamen in SFB, while the right cerebellum_crus2 and left putamen in Slow5 were higher in CP than in NP. The ALLF values of the bilateral putamen in Slow4 were increased, while the right parietal lobule in Slow4 and left upper temporal pole in Slow5 were lower in CP than in HC. The ReHo values in the CP group in the right cerebellum_crus2 was higher than that in the NP group in Slow5 (voxel < 0.05, cluster < 0.05, Gaussian Random Field theory correction). Y-balance test was correlated with cerebellum ALFF values; Tegner was moderately correlated with putamen ALFF values ( < 0.05). Knee Injury and Osteoarthritis Outcome Score-sports, International Knee Documentation Committee Subjective Knee Evaluation Form and Tegner scores were correlated with the ReHo values of right cerebellum_crus2 ( < 0.05).
Subcortical function transfer was performed in patients with ACLR who returned to sports postoperatively: the function of the somatosensory brain area decreased, while that of the subcortical cerebellum and basal ganglia and cerebellum ReHo increased in CP, which was correlated with clinical function. ALFF and ReHo are consistent to some extent, and sub-band studies can reveal information on different brain functions compared to the classical band.
本研究旨在描述前交叉韧带重建（ACLR）术后2年不同功能能力患者的神经功能差异。
对恢复运动的ACLR患者（CP）、未恢复运动的患者（NP）和健康对照者（HC）进行静息态功能磁共振成像，以获取血氧水平依赖值。计算低频波动幅度（ALFF）和局部一致性（ReHo）在标准频段（SFB，0.01 - 0.08Hz）、慢4频段（0.027 - 0.073Hz）和慢5频段（0.01 - 0.027Hz）的变化，并研究其与临床指标的相关性。
在SFB频段，CP组右侧小脑_8和双侧壳核的相关值高于NP组；在慢5频段，CP组右侧小脑蚓部2和左侧壳核的值高于NP组。慢4频段双侧壳核的ALFF值升高，而慢4频段右侧顶叶小叶和慢5频段左侧颞上极的ALFF值CP组低于HC组。慢5频段CP组右侧小脑蚓部2的ReHo值高于NP组（体素<0.05，簇<0.05，高斯随机场理论校正）。Y平衡测试与小脑ALFF值相关；Tegner评分与壳核ALFF值中度相关（<0.05）。膝关节损伤和骨关节炎疗效评分-运动版、国际膝关节文献委员会主观膝关节评估表和Tegner评分与右侧小脑蚓部2的ReHo值相关（<0.05）。
术后恢复运动的ACLR患者存在皮层下功能转移：CP组体感脑区功能下降，而皮层下小脑、基底神经节功能及小脑ReHo增加，且与临床功能相关。ALFF和ReHo在一定程度上具有一致性，与经典频段相比，子频段研究能揭示不同脑功能信息。
