Health Management Center, Huashan Hospital, Fudan University.
Department of Ophthalmology, Huashan Hospital, Fudan University; Department of Ophthalmology, Shanghai Gonghui Hospital.
J Vis Exp. 2024 Nov 1(213). doi: 10.3791/65821.
Around half of the world's population is infected with Helicobacter pylori (H. pylori), which is closely related to several ocular diseases. The study aims to evaluate the retinal and choroidal thickness changes in subjects with H. pylori infection by swept-source optical coherence tomography (SS-OCT). The ophthalmic examination and C-urea breath test (C-UBT) were performed on all subjects participating in the cross-sectional study. The participants were divided into H. pylori (+) and H. pylori (-) groups depending on the C-UBT results. This study covered 2574 right eyes from 2574 subjects with H. pylori infection and 2574 right eyes from 2574 age- and sex-matched individuals without H. pylori infection. Out of the nine sectors of the early treatment diabetic retinopathy study (ETDRS) grid, the maximum retinal thickness was in the inner superior sector, while the minimum was in the center sector. The maximum choroidal thickness was in the inner superior sector, while the minimum was in the outer nasal sector. The choroid of each area of the ETDRS subfield in the H. pylori (+) group was significantly thicker than that in the H. pylori (-) group, but retinal thickness did not show any difference between the two groups. Increased choroidal thickness may be an early indicator of H. pylori-associated retinal or choroidal diseases.
全世界约有一半的人口感染了幽门螺杆菌（H. pylori），它与多种眼部疾病密切相关。本研究旨在通过扫频源光学相干断层扫描（SS-OCT）评估 H. pylori 感染患者的视网膜和脉络膜厚度变化。所有参与横断面研究的受试者均接受眼科检查和 C-尿素呼气试验（C-UBT）。根据 C-UBT 结果，将受试者分为 H. pylori（+）组和 H. pylori（-）组。本研究共纳入 2574 例 H. pylori 感染患者的 2574 只右眼和 2574 例年龄和性别匹配的无 H. pylori 感染患者的 2574 只右眼。在早期糖尿病视网膜病变研究（ETDRS）网格的九个区域中，视网膜最厚的区域是内上方区域，最薄的区域是中心区域。脉络膜最厚的区域是内上方区域，最薄的区域是外鼻侧区域。H. pylori（+）组 ETDRS 子区域的每个区域的脉络膜厚度均显著厚于 H. pylori（-）组，但两组的视网膜厚度无差异。脉络膜厚度增加可能是 H. pylori 相关视网膜或脉络膜疾病的早期指标。
