Eye Institute of Xiamen University; School of Medicine, Xiamen University, Department of Ophthalmology, Xiang'an Hospital, Xiamen University, Xiamen, Fujian, China.
Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
J Immunol Res. 2021 Mar 24;2021:5547533. doi: 10.1155/2021/5547533. eCollection 2021.
Researches have confirmed that the retinal and choroidal thickness in patients with autoimmune disease-associated uveitis displays significant changes. However, the relationships between rheumatoid factor (RF) and thickness of the retina and choroid in individuals without ocular manifestations remain unclear. The aim of this study is to assess the associations of RF with retinal and choroidal thickness.
The individuals enrolled in the cross-sectional research received full ocular examinations. The participants were classified as the RF (+) group (RF ≥ 15.0 IU/ml) and the RF (-) group (RF < 15.0 IU/ml) according to the serum RF titers. The thickness of the retina and choroid was measured by swept-source optical coherence tomography (SS-OCT).
The study covered 65 right eyes of 65 individuals that are RF-positive and 130 right eyes of 130 age- and sex-matched individuals that are RF-negative. The RF (+) group showed decreased choroidal thickness that achieved statistical significance only in the outer inferior and outer temporal sectors, as compared to the RF (-) group. There was no statistically significant difference regarding the retinal thickness between the two groups. Pearson's correlation analysis revealed that the RF was significantly negatively related to the choroidal thickness in all areas. However, there was no significant correlation between the RF and the retinal thickness.
Serum RF titers are closely linked with choroidal thickness before the emergence of ocular symptoms. Research into the relationships may improve our understanding of the role of serum RF in the pathogenesis of uveitis.
研究已经证实，患有自身免疫性疾病相关性葡萄膜炎的患者的视网膜和脉络膜厚度会发生显著变化。然而，在没有眼部表现的个体中，类风湿因子（RF）与视网膜和脉络膜厚度之间的关系尚不清楚。本研究旨在评估 RF 与视网膜和脉络膜厚度之间的相关性。
纳入的横断面研究对象接受了全面的眼部检查。根据血清 RF 滴度将参与者分为 RF（+）组（RF≥15.0IU/ml）和 RF（-）组（RF<15.0IU/ml）。采用扫频源光学相干断层扫描（SS-OCT）测量视网膜和脉络膜的厚度。
本研究共纳入 65 名 RF 阳性个体的 65 只右眼和 130 名 RF 阴性个体的 130 只右眼。与 RF（-）组相比，RF（+）组的脉络膜厚度较薄，仅在外下和外颞象限有统计学意义。两组间视网膜厚度无统计学差异。Pearson 相关分析显示，RF 与所有区域的脉络膜厚度呈显著负相关。然而，RF 与视网膜厚度之间无显著相关性。
血清 RF 滴度与出现眼部症状前的脉络膜厚度密切相关。对这些关系的研究可能有助于我们了解血清 RF 在葡萄膜炎发病机制中的作用。
