Jordan Victoria, Mallawathantri Sugamya, Akram Ayesha, Varadhan Hemalatha
1Department of Microbiology, NSW Health Pathology, John Hunter Hospital, New Lambton Heights, NSW, Australia.
2School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
Eur J Microbiol Immunol (Bp). 2024 Nov 18;14(4):361-365. doi: 10.1556/1886.2024.00108. Print 2024 Dec 18.
Prescottella (Rhodococcus) soli is a soil-dwelling organism not previously thought to be pathogenic in humans. We discuss the case of a 78-year-old male renal transplant recipient presenting with respiratory symptoms and multiple pulmonary nodules, found to be pulmonary malakoplakia secondary to infection with Prescottella (Rhodococcus) soli. Treatment was commenced with vancomycin, meropenem and azithromycin for an induction period of two weeks and continued with indefinite oral moxifloxacin and azithromycin with significant clinical improvement. Although rare, Prescottella species, including Prescottella soli, should be considered in the differential diagnosis of pulmonary nodules, particularly in immunocompromised patients. More data is required to inform optimal treatment.
土壤红球菌以前被认为不是人类病原体。我们讨论了一名78岁男性肾移植受者的病例，该患者出现呼吸道症状和多个肺结节，经诊断为土壤红球菌感染继发的肺软斑病。开始使用万古霉素、美罗培南和阿奇霉素进行为期两周的诱导治疗，随后持续使用莫西沙星和阿奇霉素口服，治疗时间不定，患者临床症状有显著改善。尽管罕见，但在肺结节的鉴别诊断中，应考虑包括土壤红球菌在内的红球菌属，尤其是在免疫功能低下的患者中。需要更多数据来指导最佳治疗。
