Qin Xiaopeng, Qin Boli, Zhou Chenxing, Liu Chong, Chen Tianyou, Zhu Jichong, Huang Chengqian, Wu Shaofeng, He Rongqing, Wu Songze, Feng Sitan, Chen Jiarui, Xue Jiang, Wei Wendi, Chen Liyi, He Kechang, Qin Zhendong, Zhou Tiejun, Ma Jie, Zhan Xinli
The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China.
The Fourth People's Hospital of Nanning, No. 1, Lane 2, Changgang Road, Nanning, 530023, Guangxi, People's Republic of China.
J Epidemiol Glob Health. 2024 Dec;14(4):1678-1692. doi: 10.1007/s44197-024-00325-2. Epub 2024 Nov 18.
Despite continued efforts to manage and control Tuberculosis (TB) in China, it remains a major health concern. Bone tuberculosis (Bone-TB), a common form of extrapulmonary tuberculosis, still adds considerably to the global TB case load. Diagnosing Bone-TB is often difficult as its symptoms can be similar to other bone or joint diseases, which leads to delayed detection and treatment. Currently, comprehensive reports on the epidemiological aspects of Bone-TB in China are scarce.
This retrospective study analyzed demographic and clinical data from 2,191 patients diagnosed with Bone-TB in Southwest China between January 2011 and September 2023.This study fully reveals the characteristics of Bone-TB in Southwest China.
The overall trend of bone tuberculosis was a slow rise. Among 2191 patients, males, farmers, aged 42-68 years, and people with HIV and diabetes are the priority groups for the prevention and treatment of Bone-TB. The majority of the infected spines (1556/2191) were located in the thoracic vertebra (759/2191) and lumbar vertebra (715/2191). Forty-nine (2.24%) patients had drug-resistant TB (DR-TB). Forty-five (2.05%) died during the treatment. The total and actual hospitalization. Costs amounted to $3,837.10 and $1,914.35 (p < 0.01). Patients with DR-TB incurred the highest costs, amounting to $4,968.37. Cervical TB, with a prevalence of 5 patients (6.10%), exhibited the highest rates of catastrophic expenditures.
From 2011 to 2023, the yearly occurrence of Bone-TB in southwestern China exhibited a rising pattern, marked by notable distinctions in terms of gender, age, and regional variations, indicating localized clustering characteristics.
尽管中国在结核病（TB）的管理和控制方面持续努力，但它仍然是一个主要的健康问题。骨结核是肺外结核的一种常见形式，仍然在全球结核病病例负担中占相当大的比例。骨结核的诊断通常很困难，因为其症状可能与其他骨骼或关节疾病相似，这导致检测和治疗延迟。目前，关于中国骨结核流行病学方面的综合报告很少。
这项回顾性研究分析了2011年1月至2023年9月在中国西南部被诊断为骨结核的2191例患者的人口统计学和临床数据。这项研究充分揭示了中国西南部骨结核的特征。
骨结核的总体趋势呈缓慢上升。在2191例患者中，男性、农民、42至68岁的人群以及感染艾滋病毒和糖尿病的人是骨结核预防和治疗的重点人群。大多数受感染的脊柱（1556/2191）位于胸椎（759/2191）和腰椎（715/2191）。49例（2.24%）患者患有耐药结核病（DR-TB）。45例（2.05%）患者在治疗期间死亡。总住院费用和实际住院费用分别为3837.10美元和1914.35美元（p<0.01）。耐多药结核病患者的费用最高，达4968.37美元。颈椎结核患病率为5例（6.10%），灾难性支出率最高。
2011年至2023年，中国西南部骨结核的年发病率呈上升趋势，在性别、年龄和区域差异方面存在显著差异，呈现出局部聚集特征。
