Uniformed Services University of the Health Sciences, Scott Air Force Base, Ill.
Malcolm Grow Medical Clinics and Surgical Center, Joint Base Andrews, Md.
Am Fam Physician. 2024 Nov;110(5):504-514.
Easy bruising and bleeding are commonly seen in primary care. Use of a bleeding assessment tool and a comprehensive history, physical examination, and patient-provided photographs can help identify causes of abnormal bleeding and bruising. Family history can aid diagnosis of a heritable cause. Nonaccidental trauma should be considered, especially in vulnerable populations. Initial laboratory testing includes a complete blood cell count, peripheral blood smear, prothrombin time (PT), international normalized ratio, activated partial thromboplastin time (aPTT), and fibrinogen. Normal PT and aPTT results may indicate a platelet disorder. A normal PT result with a prolonged aPTT result indicates a disorder of the intrinsic coagulation pathway, and a prolonged PT result with a normal aPTT result may indicate a disorder of the extrinsic coagulation pathway. Consultation with a hematologist is recommended when initial evaluation indicates a bleeding disorder or when suspicion remains high despite a normal laboratory workup result.
在初级保健中,容易瘀伤和出血很常见。使用出血评估工具以及全面的病史、体格检查和患者提供的照片有助于确定异常出血和瘀伤的原因。家族史有助于诊断遗传性病因。应考虑非故意外伤,尤其是在弱势群体中。初始实验室检查包括全血细胞计数、外周血涂片、凝血酶原时间 (PT)、国际标准化比值、活化部分凝血活酶时间 (aPTT) 和纤维蛋白原。正常的 PT 和 aPTT 结果可能表明血小板异常。正常的 PT 结果伴延长的 aPTT 结果提示内在凝血途径异常,而正常的 PT 结果伴延长的 aPTT 结果可能提示外在凝血途径异常。当初步评估表明存在出血性疾病,或者尽管实验室检查结果正常但仍高度怀疑时,建议咨询血液科医生。