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中医治疗原发性肝癌 TACE 术后不良反应的疗效、机制及潜在优势。

Traditional Chinese medicine in the treatment of adverse reactions after TACE for primary hepatic carcinoma: Effect, mechanism, and potential advantages.

机构信息

Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen 361102, China.

Department of Clinical Medicine, School of Medicine, Xiamen University, Xiamen 361102, China.

出版信息

Phytomedicine. 2024 Dec;135:156244. doi: 10.1016/j.phymed.2024.156244. Epub 2024 Nov 9.

DOI:10.1016/j.phymed.2024.156244
PMID:39556987
Abstract

Primary hepatic carcinoma is one of the most common malignant tumors. China is a major country for liver cancer, accounting for about 50 % of the patients worldwide. Although there are a variety of treatments for primary hepatic carcinoma, chemotherapy remains an important method, and transcatheter arterial chemoembolization (TACE) is a commonly used local chemotherapy. Currently, there are no effective therapeutic measures to target adverse reactions generated after chemoembolization. A new approach is needed to alleviate post-TACE syndrome. Clinical and experimental studies have shown that traditional Chinese medicine can reduce adverse reactions and improve clinical efficacy when combined with primary hepatic carcinoma treatment. This suggests that traditional Chinese medicine plays an important and irreplaceable role in alleviating adverse reactions after TACE. However, there is still a need for high-quality experimental and clinical studies to obtain evidence of effective treatment.

摘要

原发性肝癌是最常见的恶性肿瘤之一。中国是肝癌的高发国家,约占全球肝癌患者的 50%。尽管有多种治疗原发性肝癌的方法,但化疗仍然是一种重要的方法,经导管肝动脉化疗栓塞术(TACE)是一种常用的局部化疗方法。目前,针对化疗栓塞后产生的不良反应还没有有效的治疗措施。需要一种新的方法来缓解 TACE 后综合征。临床和实验研究表明,中药结合原发性肝癌治疗可以减轻不良反应,提高临床疗效。这表明中药在缓解 TACE 后不良反应方面发挥着重要且不可替代的作用。然而,仍然需要高质量的实验和临床研究来获得有效的治疗证据。

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