Bloom J W, Halonen M, Dunn A M, Pinnas J L, Burrows B
Clin Allergy. 1986 Jan;16(1):25-32. doi: 10.1111/j.1365-2222.1986.tb01950.x.
A relationship between elevated serum immunoglobulin E levels and smoking has been demonstrated in epidemiological studies. Allergy skin test data suggest that the excess immunoglobulin E of smokers is not specific for aeroallergens. It is possible that the excess immunoglobulin E is specific for microorganisms that often infect the lower respiratory tract of smokers. To investigate this possibility we utilized a radioallergosorbent test assay for detecting serum immunoglobulin E specific for Streptococcus pneumoniae, an organism commonly isolated from the respiratory tract of smokers with chronic bronchitis. We assayed sera of thirty smokers and thirty nonsmokers for immunoglobulin E specific for Streptococcus pneumoniae. Individual sera were considered positive for pneumococcus-specific immunoglobulin E if the binding was at least twice the non-specific binding at the total immunoglobulin E concentration of the particular serum. Eleven of the thirty sera of smokers and two of the thirty nonsmokers were positive for pneumococcus-specific immunoglobulin E. By chi-square analysis of these data, the prevalence of pneumococcus-specific immunoglobulin E was significantly greater in the smoking group compared with the non-smoking group (P less than 0.02). These results suggest that the excess immunoglobulin E of smokers is, at least in part, specific for microorganisms that infect the airways.
流行病学研究已证实血清免疫球蛋白E水平升高与吸烟之间存在关联。变应原皮肤试验数据表明，吸烟者体内过量的免疫球蛋白E并非针对气传变应原具有特异性。过量的免疫球蛋白E有可能是针对经常感染吸烟者下呼吸道的微生物具有特异性。为了探究这种可能性，我们采用放射变应原吸附试验来检测针对肺炎链球菌的血清免疫球蛋白E，肺炎链球菌是一种常见于患有慢性支气管炎的吸烟者呼吸道中的微生物。我们检测了30名吸烟者和30名非吸烟者血清中针对肺炎链球菌的免疫球蛋白E。如果在特定血清的总免疫球蛋白E浓度下，结合量至少是非特异性结合量的两倍，则个体血清被认为对肺炎球菌特异性免疫球蛋白E呈阳性。30名吸烟者的血清中有11份以及30名非吸烟者的血清中有2份对肺炎球菌特异性免疫球蛋白E呈阳性。通过对这些数据进行卡方分析，吸烟组中肺炎球菌特异性免疫球蛋白E的患病率显著高于非吸烟组（P小于0.02）。这些结果表明，吸烟者体内过量的免疫球蛋白E至少部分是针对感染气道的微生物具有特异性。
