Panteghini M, Bonora R, Malchiodi A, Calarco M
Clin Biochem. 1986 Feb;19(1):20-5. doi: 10.1016/s0009-9120(86)80066-2.
A new instrument (NOVA 4 + 4) designed to measure serum chloride by ion-selective electrode (ISE)-direct potentiometry (without sample dilution) was evaluated and compared with two widely used methodologies for chloride determination. Mean values obtained with the Nova were significantly higher than those obtained by a colorimetric method and by coulometric titration. Unlike these procedures, which are performed after sample dilution, direct potentiometry was unaffected by changes in plasma water caused by hyperlipemia and/or high protein concentrations. The only important interference was falsely high choride caused by administered bromide or iodide. Therefore, the direct potentiometric method should be more accurate than the colorimetric or coulometric procedures, especially when plasma lipids or proteins are very high.
对一种新的通过离子选择电极（ISE）直接电位分析法（无需样品稀释）测量血清氯化物的仪器（NOVA 4 + 4）进行了评估，并与两种广泛使用的氯化物测定方法进行了比较。用该仪器获得的平均值显著高于比色法和库仑滴定法获得的平均值。与这些在样品稀释后进行的方法不同，直接电位分析法不受高脂血症和/或高蛋白浓度引起的血浆水分变化的影响。唯一重要的干扰因素是服用溴化物或碘化物导致氯化物假性升高。因此，直接电位分析法应该比色法或库仑法更准确，尤其是当血浆脂质或蛋白质含量非常高时。
