Nagamine Y, Hamai Y, Chikamori K, Kita T, Hirota M, Oshima I, Yamashita S, Shima K
Department of Laboratory Medicine, Tokushima University School of Medicine, Japan.
Scand J Clin Lab Invest. 1988 Apr;48(2):177-82. doi: 10.3109/00365518809085410.
Six patients were found to have increased serum chloride concentrations when these concentrations were determined with an ion-selective electrode, but not when determined by continuous flow mercuric thiocyanate colorimetry or amperometric-coulometric titration. Their serum bromide levels of 1.8-8.0 mmol/l were much higher than those of 0.07-0.13 mmol/l in normal controls. The urinary bromide excretion, measured in two of these patients, was higher than that in normal subjects. No common symptoms or abnormalities in laboratory findings except hyperbromidaemia were found in these patients, who claimed not to have taken any drugs containing bromide. For determination of the incidence of subclinical hyperbromidaemia, the serum bromide concentrations were measured in sera of 1,323 outpatients sent to Tokushima University Hospital for routine measurements of blood chemistry over a one-month period. Five samples showed abnormally high bromide levels. It is concluded that subclinical hyperbromidaemia is not as rare as generally thought, though the aetiology of this state is unknown. Chloride determination with an ion-selective electrode can be used to screen for hyperbromidaemia, since increased levels of bromide ion result in apparently high chloride values.
用离子选择电极测定时，发现6例患者血清氯化物浓度升高，但用连续流动汞硫氰酸盐比色法或安培 - 库仑滴定法测定时则未升高。他们的血清溴水平为1.8 - 8.0 mmol/l，远高于正常对照组的0.07 - 0.13 mmol/l。对其中2例患者测定的尿溴排泄量高于正常受试者。这些患者除高溴血症外未发现常见症状或实验室检查异常，且他们声称未服用任何含溴药物。为确定亚临床高溴血症的发生率，在一个月内对送往德岛大学医院进行血液化学常规检测的1323例门诊患者的血清进行了溴浓度测定。有5份样本显示溴水平异常高。结论是，尽管这种状态的病因不明，但亚临床高溴血症并不像通常认为的那样罕见。由于溴离子水平升高会导致氯化物值明显升高，因此可用离子选择电极测定氯化物来筛查高溴血症。
