血清雄激素和性激素结合球蛋白水平在女性多毛症评估中的作用

Role of serum androgens and sex hormone binding globulin capacity in the evaluation of hirsutism in women.

作者信息

Andreyko J L, Bhavnani B R, Nisker J A, Walker W H, Woolever C A

出版信息

Clin Biochem. 1986 Feb;19(1):58-61. doi: 10.1016/s0009-9120(86)80074-1.

Abstract

Serum samples from 23 hirsute women and 23 non-hirsute women matched for age and deviation from ideal weight were analyzed for total testosterone (T), percent free testosterone (% FT) and sex hormone binding globulin capacity (SHBG). The % FT was assayed by 2 methods, using diluted serum in equilibrium dialysis (EQD) and using undiluted serum in centrifugal ultra-filtration (UF). SHBG was measured by a DEAE cellulose filter assay and T by radioimmunoassay. The two methods for determining % FT correlated well. There was considerable overlap between the hirsute and control groups for all of the measured parameters. The discrimination between the 2 groups provided by the indirect estimate of free testosterone obtained from the ratio of T to SHBG was at least as good as that provided by the free testosterone derived from ultrafiltration or dialysis.

摘要

对23名多毛女性和23名年龄及体重偏离理想值相匹配的非多毛女性的血清样本进行了总睾酮（T）、游离睾酮百分比（%FT）和性激素结合球蛋白容量（SHBG）分析。采用两种方法测定%FT，一种是在平衡透析（EQD）中使用稀释血清，另一种是在离心超滤（UF）中使用未稀释血清。通过DEAE纤维素滤膜分析法测定SHBG，通过放射免疫分析法测定T。两种测定%FT的方法相关性良好。在所有测量参数方面，多毛组和对照组之间存在相当大的重叠。通过T与SHBG的比值间接估算游离睾酮来区分两组的效果，至少与超滤或透析法得出的游离睾酮效果相当。