GenBank 2025年更新版。

GenBank 2025 update.

作者信息

Sayers Eric W, Cavanaugh Mark, Frisse Linda, Pruitt Kim D, Schneider Valerie A, Underwood Beverly A, Yankie Linda, Karsch-Mizrachi Ilene

机构信息

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

出版信息

Nucleic Acids Res. 2025 Jan 6;53(D1):D56-D61. doi: 10.1093/nar/gkae1114.

DOI:10.1093/nar/gkae1114

PMID:39558184

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11701615/

Abstract

GenBank® (https://www.ncbi.nlm.nih.gov/genbank/) is a comprehensive, public data repository that contains 34 trillion base pairs from over 4.7 billion nucleotide sequences for 581 000 formally described species. Daily data exchange with the European Nucleotide Archive and the DNA Data Bank of Japan ensures worldwide coverage. We summarize the content of the database in 2025 and recent updates such as accelerated processing of influenza sequences and the ability to upload feature tables to Submission Portal for messenger RNA sequences. We provide an overview of the web, application programming and command-line interfaces that allow users to access GenBank data. We also discuss the importance of creating BioProject and BioSample records during submissions, particularly for viruses and metagenomes. Finally, we summarize educational materials and recent community outreach efforts.

摘要

GenBank®（https://www.ncbi.nlm.nih.gov/genbank/）是一个综合性的公共数据储存库，包含来自58.1万个正式描述物种的超过47亿个核苷酸序列的34万亿个碱基对。与欧洲核苷酸档案库和日本DNA数据库的每日数据交换确保了全球覆盖。我们总结了2025年该数据库的内容以及近期的更新，如流感序列的加速处理和向提交门户上传信使核糖核酸序列特征表的能力。我们概述了允许用户访问GenBank数据的网络、应用程序编程和命令行界面。我们还讨论了在提交过程中创建生物项目和生物样本记录的重要性，特别是对于病毒和宏基因组。最后，我们总结了教育材料和近期的社区推广工作。