Pathology Department, Basaksehir Cam and Sakura City Hospital, Basaksehir, Istanbul, 34480, Turkey.
Pathology Department, Health Sciences University Kartal Dr Lutfi Kırdar City Hospital, Kartal, 34865, Istanbul, Turkey.
BMC Geriatr. 2024 Nov 18;24(1):960. doi: 10.1186/s12877-024-05500-5.
The lesions observed in very old populations exhibit a wide spectrum of characteristics. Histopathological evaluation may be necessary for accurate diagnosis in this demographic. There is limited amount of data on the histopathological evaluation of lesions in very old patients. Therefore, the aim of this study was to assess the histopathological features in this population.
A total of 5376 pathological samples from very old patients (≥ 80 years old) were analyzed. Clinical and pathological data were retrospectively reviewed. Histopathological diagnoses were categorized into three groups: malignant (invasive) lesions (MLs), benign/inflammatory lesions (BLs), and dysplastic-dysmorphic/non-invasive malignant lesions (DLs). Statistical analyses were conducted on the histopathological data. Pearson's chi-square test and the Fisher exact test were used to analyze the data, and statistical significance was considered at a p-value of < 0.05.
The mean age of the patients was 83.6 ± 3.4 years (range: 80-107), with 53% being female. The upper gastrointestinal (GI) tract was the most common site among all materials (28%, n = 1524). Benign/inflammatory lesions (BLs) accounted for the highest proportion of cases (62%, n = 3322) compared to MLs and DLs. BLs were significantly more prevalent in female patients (p < 0.001). MLs were notably more common in biopsies from breast locations (p < 0.001). No patients were diagnosed with DLs in the cytological materials.
Despite the broad spectrum of lesions observed in very old patients, the majority tend to be benign. While the Coronavirus disease 2019 (COVID-19) pandemic has altered healthcare dynamics, the increased frequency of benign lesions among the very old population, as a result of more frequent healthcare facility visits, is noteworthy. However, dysplastic and malignant lesions remain significant in this population and can profoundly impact patients' quality of life. This study contributes to our understanding of histopathological diagnoses in the very old population, shedding light on the current approach to managing their pathological specimens.
在非常高龄的人群中观察到的病变具有广泛的特征。在这一年龄段，进行准确的诊断可能需要进行组织病理学评估。关于非常高龄患者病变的组织病理学评估，数据非常有限。因此，本研究旨在评估该人群的组织病理学特征。
分析了 5376 例来自非常高龄患者（≥80 岁）的病理样本。回顾性分析了临床和病理学数据。组织病理学诊断分为三组：恶性（侵袭性）病变（MLs）、良性/炎症性病变（BLs）和发育不良/发育不良/非侵袭性恶性病变（DLs）。对组织病理学数据进行了统计分析。使用 Pearson's chi-square 检验和 Fisher 确切检验进行数据分析，以 p 值 < 0.05 为统计学意义。
患者的平均年龄为 83.6±3.4 岁（范围：80-107 岁），女性占 53%。上消化道（GI）是所有材料中最常见的部位（28%，n=1524）。良性/炎症性病变（BLs）占病例的比例最高（62%，n=3322），明显高于 MLs 和 DLs。BLs 在女性患者中更为常见（p<0.001）。MLs 在乳房活检中更为常见（p<0.001）。在细胞学材料中没有患者被诊断为 DLs。
尽管在非常高龄的患者中观察到的病变范围广泛，但大多数倾向于良性。尽管 2019 年冠状病毒病（COVID-19）大流行改变了医疗保健动态，但由于更频繁地前往医疗机构就诊，非常高龄人群中良性病变的频率增加值得关注。然而，发育不良和恶性病变在该人群中仍然很重要，会对患者的生活质量产生重大影响。本研究有助于我们了解非常高龄人群的组织病理学诊断，为管理他们的病理标本提供了当前的方法。
