Department of cardiology and macrovascular disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of laboratory, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Clin Cardiol. 2024 Nov;47(11):e70050. doi: 10.1002/clc.70050.
Orthostatic hypotension (OH) is associated with different cardiovascular diseases, however, the association between OH and coronary slow flow (CSF) has never been evaluated before.
Chest pain patients who underwent coronary angiography (CAG) and with normal coronary arteries in our department from January 1st, 2022 to August 31st, 2023 were retrospectively enrolled. Patients were divided into the CSF group and the normal blood flow (NBF) group. Relative clinical information, laboratory test results as well as the results of CAG were collected and analyzed. Both uni-variable and multi-variable logistic regression analyses were used to evaluate the association between OH and CSF in these patients.
Four thousand six hundred and twenty-seven patients underwent CAG and 655 patients had normal coronary arteries. In which, sixty-nine patients were diagnosed with CSF while 586 patients were diagnosed with NBF. Uni-variable analysis revealed that higher body weight index, faster heart rate in sitting position, accompanied with chronic kidney disease, did not take Antidiabetic therapy, higher level of aspartate transaminase, uric acid, triglyceride, total cholesterol, ApoB1, low-density lipoprotein cholesterol, homocysteine, B-type natriuretic peptide as well as OH are the risk factors for CSF in these patients. Multi-variable logistic regressing analysis further demonstrated that OH was the independent risk factor for predicting CSF in these patients.
Our finding suggests OH might be a useful predictor for CSF in patients with chest pain but normal coronary arteries.
直立性低血压（OH）与多种心血管疾病相关，但 OH 与冠状动脉慢血流（CSF）之间的关联尚未得到评估。
回顾性纳入 2022 年 1 月 1 日至 2023 年 8 月 31 日在我院行冠状动脉造影（CAG）且冠状动脉正常的胸痛患者。将患者分为 CSF 组和正常血流（NBF）组。收集并分析了相对临床信息、实验室检查结果以及 CAG 结果。采用单变量和多变量逻辑回归分析评估 OH 与这些患者 CSF 之间的关系。
共 4627 例行 CAG 检查，655 例冠状动脉正常。其中，69 例诊断为 CSF，586 例诊断为 NBF。单变量分析显示，较高的体重指数、坐位心率较快、合并慢性肾脏病、未接受糖尿病治疗、较高的天门冬氨酸转氨酶、尿酸、甘油三酯、总胆固醇、载脂蛋白 B1、低密度脂蛋白胆固醇、同型半胱氨酸、B 型利钠肽以及 OH 是这些患者 CSF 的危险因素。多变量逻辑回归分析进一步表明，OH 是预测这些患者 CSF 的独立危险因素。
我们的研究结果表明，OH 可能是胸痛但冠状动脉正常患者 CSF 的有用预测指标。
