Department of Cardiology, The People's Hospital of Liaoning Province, The People's Hospital of China Medical University, Shenyang, China.
BMC Cardiovasc Disord. 2024 Jul 13;24(1):358. doi: 10.1186/s12872-024-04040-5.
The plasma uric acid to albumin ratio (UAR) is considered as a novel indicator for Inflammation. However, the association between UAR and coronary slow flow phenomenon (CSFP) remains unclear.
A total of 1328 individuals with chronic coronary syndrome (CCS) receiving coronary angiography (CAG) and found no obvious obstructive stenosis (< 40%) were included in this study. 79 individuals developed CSFP and were divided into CSFP group. The 1:2 age-matched patients with normal coronary blood flow were allocated to the control group (n = 158). The clinical characteristics, laboratory parameters including uric acid, albumin ratio, UAR and the angiographic characteristics were compared between the two groups.
Patients with CSFP had a higher level of uric acid (392.3 ± 85.3 vs. 273.8 ± 71.5, P < 0.001), UAR (10.7 ± 2.2 vs. 7.2 ± 1.9, P < 0.001), but a lower level of plasma albumin (36.9 ± 4.2 vs. 38.5 ± 3.6, P = 0.003). Moreover, UAR increased as the numbers of vessels involved in CSFP increased. The logistic regression analysis demonstrated that UAR was independent predictors for CSFP. The Receiver operating characteristic (ROC) curve analysis showed that when UAR was more than 7.9, the AUC was 0.883 (95% CI: 0.840-0.927, p < 0.001), with the sensitivity and specificity were 78.2% and 88.2% respectively.
Combined uric acid with plasma albumin, UAR could serve as an independent predictor for CSFP.
血浆尿酸与白蛋白比值（UAR）被认为是炎症的一个新指标。然而，UAR 与冠状动脉慢血流现象（CSFP）之间的关系尚不清楚。
本研究共纳入 1328 例接受冠状动脉造影（CAG）且无明显阻塞性狭窄（<40%）的慢性冠状动脉综合征（CCS）患者。其中 79 例发生 CSFP，分为 CSFP 组。将年龄匹配的 1：2 例血流正常的患者分为对照组（n=158）。比较两组的临床特征、实验室参数（包括尿酸、白蛋白比值、UAR）和血管造影特征。
CSFP 患者尿酸水平较高（392.3±85.3 比 273.8±71.5，P<0.001），UAR 较高（10.7±2.2 比 7.2±1.9，P<0.001），但血浆白蛋白水平较低（36.9±4.2 比 38.5±3.6，P=0.003）。此外，随着 CSFP 受累血管数量的增加，UAR 也随之增加。Logistic 回归分析表明，UAR 是 CSFP 的独立预测因子。受试者工作特征（ROC）曲线分析显示，当 UAR 大于 7.9 时，AUC 为 0.883（95%CI：0.840-0.927，p<0.001），敏感性和特异性分别为 78.2%和 88.2%。
尿酸联合血浆白蛋白，UAR 可作为 CSFP 的独立预测因子。
