Patel Aman M, Desai Amar D, Revercomb Lucy, Behbahani Sara, Filimonov Andrey
Rutgers New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103 USA.
Department of Dermatology, Brigham and Women's Hospital, Boston, MA USA.
Indian J Otolaryngol Head Neck Surg. 2024 Dec;76(6):5771-5776. doi: 10.1007/s12070-024-05089-6. Epub 2024 Oct 1.
Head and neck dermatofibrosarcoma protuberans (HNDFSP) is a rare neoplasm with a high rate of local infiltration and local recurrence but a low rate of distant metastasis. Given the limited literature on HNDFSP and existing studies pointing to possible racial and ethnic differences, further research is needed to understand important clinical correlates that may impact treatment and prognosis. The National Cancer Database (NCDB) was queried for all cases of HNDFSP diagnosed from 2004 to 2016. Demographic characteristics of the included patients were compared using chi-squared and t-tests. Kaplan-Meier and Cox multivariable regression analyses were performed to assess survival differences. Of the 778 included patients, 526 (67.6%) patients were white, 113 (14.5%) were black, 33 (4.2%) were Asian, 87 (11.2%) were Hispanic, and 19 (2.4%) were classified as Other. White patients presented at a significantly older age (43.8 years) than did black (38.9 years) and Hispanic patients (37.9 years) ( = 0.02). White patients with HNDFSP had significantly higher income status ( = 0.0001), were more likely to be insured ( = 0.0001), and were more likely to have a high school diploma ( = 0.0001). There were no significant racial differences in 5-year (96.1%) or 10-year (92.0%) overall survival. None of the variables yielded a statistically significant value in Cox analysis. Differences exist in HNDFSP presentation between racial groups. Specifically, differences in income, insurance status, education level, and age of presentation exist between these groups. Future studies focused on morbidity are needed to better understand the consequences of these difference on HNDFSP patients.
头颈部隆突性皮肤纤维肉瘤（HNDFSP）是一种罕见肿瘤，局部浸润和局部复发率高，但远处转移率低。鉴于关于HNDFSP的文献有限，且现有研究指出可能存在种族和民族差异，因此需要进一步研究以了解可能影响治疗和预后的重要临床相关因素。查询了国家癌症数据库（NCDB）中2004年至2016年诊断的所有HNDFSP病例。使用卡方检验和t检验比较纳入患者的人口统计学特征。进行了Kaplan-Meier和Cox多变量回归分析以评估生存差异。在纳入的778例患者中，526例（67.6%）为白人，113例（14.5%）为黑人，33例（4.2%）为亚洲人，87例（11.2%）为西班牙裔，19例（2.4%）归类为其他。白人患者的就诊年龄（43.8岁）明显高于黑人（38.9岁）和西班牙裔患者（37.9岁）（P = 0.02）。患有HNDFSP的白人患者收入状况明显更高（P = 0.0001），更有可能参保（P = 0.0001），并且更有可能拥有高中文凭（P = 0.0001）。5年（96.1%）或10年（92.0%）总生存率无显著种族差异。在Cox分析中，没有变量产生具有统计学意义的值。不同种族群体的HNDFSP表现存在差异。具体而言，这些群体在收入、保险状况、教育水平和就诊年龄方面存在差异。需要开展关注发病率的未来研究，以更好地了解这些差异对HNDFSP患者的影响。
