R Chethana, Chutke Amruta, Jadhav Rohit, Ramanathan Siddharth, Shamkant Shamli
Department of ENT Bharati Vidyapeet (Deemed to be), University Medical college, Pune, 411046 Maharashtra India.
Bharati Hospital and Research Centre Pune, 411046 Maharashtra, India.
Indian J Otolaryngol Head Neck Surg. 2024 Dec;76(6):5812-5817. doi: 10.1007/s12070-024-05109-5. Epub 2024 Oct 5.
To determine salivary pH in patients with Laryngopharyngeal Reflux (LPR) and compare it with that of normal individuals. A cross sectional analytical study was done. Adults with LPR as determined by Reflux Symptom Index (RSI) > 13 and Reflux Finding Score (RFS) > 7 were included in LPR group. Normal healthy adult participants with Reflux Symptom Index ≤ 3 and Reflux Finding Score ≤ 2 were included in non LPR group.32 participants were included in each groups. Salivary pH was determined in all participants using a standardized pH meter. Difference in salivary pH between two groups was statistically analyzed. The mean salivary pH in LPR group was 7.43 ± 0.77 and in non LPR group 7.0 ± 0.77. There was a statistically significant difference between the mean salivary pH between the two groups as determined by p value 0.004. The results of our exploratory study showed statistically significant difference in salivary pH between LPR and non LPR group. The salivary pH in 10(31.2%) out of 32 participants in LPR group was beyond the normal range and surprisingly the value was > 7.6, which was in contrast to acidic pH that was expected as per hypothesis. The rest 68.8% in LPR group had pH in the normal range. However salivary pH as a modality for diagnosing LPR cannot be concluded from such preliminary study with a small study population. This study forms a basis for future research for the role of salivary pH in LPR with better study designs and finer modalities of pH testing.
测定喉咽反流（LPR）患者的唾液pH值，并与正常个体进行比较。进行了一项横断面分析研究。反流症状指数（RSI）>13且反流发现评分（RFS）>7的LPR成年患者被纳入LPR组。反流症状指数≤3且反流发现评分≤2的正常健康成年参与者被纳入非LPR组。每组纳入32名参与者。使用标准化pH计测定所有参与者的唾液pH值。对两组之间唾液pH值的差异进行统计学分析。LPR组的平均唾液pH值为7.43±0.77，非LPR组为7.0±0.77。根据p值0.004确定，两组之间的平均唾液pH值存在统计学显著差异。我们的探索性研究结果显示，LPR组和非LPR组之间的唾液pH值存在统计学显著差异。LPR组32名参与者中有10名（31.2%）的唾液pH值超出正常范围，令人惊讶的是该值>7.6，这与假设中预期的酸性pH值相反。LPR组其余68.8%的参与者pH值在正常范围内。然而，不能从这样一个小研究人群的初步研究中得出唾液pH值作为诊断LPR的一种方式的结论。本研究为未来关于唾液pH值在LPR中的作用的研究奠定了基础，采用更好的研究设计和更精细的pH测试方式。
