A Study of the Influence of Meteorological and Environmental Factors on Otitis Media with Effusion in Lanzhou.

In observational studies, a possible correlation between atmospheric environmental factors and the number of daily outpatient visits by Otitis media with effusion(OME) patients has been observed. However, the causal relationship is not clear.To study the relationship between the incidence of OME and meteorological factors and air pollutants in the main urban areas of Lanzhou, it is helpful to further understand the health effects of meteorological and environmental factors on OME and to prevent and treat the disease, it is of great academic and practical significance to the prevention, treatment and prognosis of diseases. The levels of AQI、PM2.5、PM10、NO、O、SO、CO、AP、RH、W and T were obtained from local monitor stations. Data of patients with OME were collected from two Grade A Level hospitals in Lanzhou from January 1, 2014 to December 31, 2016. Descriptive analysis of data was carried out for the study subjects. Spearman correlation coefficients between atmospheric environmental factors and daily visits of patients with OME were calculated by SPSS statistical software. Lag effects, relative risks(RR) and exposure-response curves were calculated by generalized additive model (GAM) with R software. (1) The incidence of OME in winter and spring was more than that in summer and autumn, which was consistent with the seasonal variation of meteorological environmental factors of Lanzhou. That was, the meteorological conditions and air quality in winter and spring were poor, while in summer and autumn they were relatively good. (2) The number of male outpatients were 1.05, 1.08 and 1.09 times of female outpatients during the period 2014-2016, respectively. And aged 0-10 years old outpatients accounted for 31% of the total OME outpatients. (3) Exposure-response curve showed that PM2.5, PM10, NO and SO were positively correlated with OME, T was negatively correlated with OME. When concentration < 1mg/m, CO was positively correlated with OME. When concentration>1mg/m, CO was negatively correlated with OME. When concentration<30 ug/m, O was positively correlated with OME. When concentration>30ug/m, O was negatively correlated with OME. (4) The factors we studied could significantly affect the number of OME outpatients within 2-3 days of single lag effects, and 3-4 days of cumulative lag effects.(5) The influential factors on OME were as follows: PM2.5、NO、SO、O、 CO and T. The daily average number of OME patients in different seasons was different in major region of Lanzhou city, with more in winter、spring and fewer in summer、autumn. Age and sex were the important factors affecting the daily average number of OME patients. Males were more susceptible to OME than females and children awere moresusceptible to OME than adults. The change of OME patients was related to air quality, air pressure and temperature. The worse the air quality, the higher the air pressure, the lower the temperature, the more the average daily number of OME patients. Meteorological environmental factors affected the visits of OME, and the lagging effect time of different factors were different. Most of the research factors within 3-4 days had a significant impact on the number of patients of OME. 1.The number of OME visits in the Lanzhou was more seasonal in winter and spring than in summer and fall. 2.Age and sex were the most important factors affecting the number of patients with OME. According to the prevalence of OME in Lanzhou, children were more likely to have OME than adults and men were more likely to have OME than women. 3.The number of OME patients was related to air quality, air pressure and temperature. 4.The meteorological factors have a delayed effect on the onset of OME, and the time of delayed effect is different for different factors. The single delayed effect of 2-3 days and the cumulative delayed effect of 3-4 days have a significant effect on the change of the number of patients with OME. To study the relationship between the incidence of OME and meteorological factors and air pollutants in the main urban areas of Lanzhou, it is helpful to further understand the health effects of meteorological and environmental factors on OME and to prevent and treat the disease, it is of great academic and practical significance to the prevention, treatment and prognosis of diseases.