Wang Xiaodong, Shou Chunhui, Zhu Kankai, Yang Weili, Yu Jiren
Gastroenterology Department, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Int Med Case Rep J. 2024 Nov 14;17:965-969. doi: 10.2147/IMCRJ.S488459. eCollection 2024.
A new lump in patients with a history of gastrointestinal stromal tumor (GIST) may indicate resistance to medication and recurrence. It is important to monitor for recurrence or metastasis after surgery for GIST, especially in cases of high-risk GIST, as it determines the subsequent treatment. However, it is difficult to differentiate between GIST and DF by imaging. Tissue biopsy and final diagnosis through pathological analysis are usually required. Here, we report 2 cases of primary diagnosis with high-risk GIST and suspected tumor recurrence during Imatinib treatment. The mass was not located where the previous GIST lesion had been. After the complete excision of the mass through laparoscopic surgery, the pathological findings revealed that it was not a recurrence of GIST, but a desmoid-type fibromatosis.
有胃肠道间质瘤（GIST）病史的患者出现新肿块可能提示对药物耐药及复发。对GIST患者术后进行复发或转移监测很重要，尤其是高危GIST患者，因为这决定后续治疗。然而，通过影像学很难区分GIST和硬纤维瘤病（DF）。通常需要进行组织活检并通过病理分析进行最终诊断。在此，我们报告2例原发性高危GIST诊断病例及伊马替尼治疗期间疑似肿瘤复发的情况。肿块并非位于先前GIST病变所在位置。通过腹腔镜手术完整切除肿块后，病理结果显示其并非GIST复发，而是韧带样型纤维瘤病。
