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转移性透明细胞肾细胞癌的自发消退：1例罕见病例报告及文献复习

Spontaneous regression of metastatic clear cell renal cell carcinoma: A report of a rare case and a review of the literature.

作者信息

Mullasseril Anoushka, Lam Anh B, Mitta Alekhya, Morton Daniel, McIntosh Andrew, Patel Sanjay, Thai Theresa, Annan Anand, Ayanambakkam Adanma

机构信息

Department of Internal Medicine, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.

Department of Radiation Oncology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.

出版信息

Urol Case Rep. 2024 Oct 9;57:102868. doi: 10.1016/j.eucr.2024.102868. eCollection 2024 Nov.

DOI:10.1016/j.eucr.2024.102868
PMID:39559476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11570451/
Abstract

Renal cell carcinoma (RCC) is the seventh most common cancer in the United States; clear cell RCC (ccRCC) is the most common subtype. We report a case of spontaneous regression of metastatic ccRCC and discuss possible underlying mechanisms informed by a literature review. While regression of metastatic RCC has been described following nephrectomy or treatment of the primary tumor, spontaneous regression is rare. Postulated underlying causes include tumor necrosis and immune-mediated responses. Of 29 identified cases of spontaneous regression, only ours occurred after only a biopsy. Better understanding of the pathophysiology of spontaneous regression in RCC will improve its management.

摘要

肾细胞癌（RCC）是美国第七大常见癌症；透明细胞肾细胞癌（ccRCC）是最常见的亚型。我们报告一例转移性ccRCC自发消退的病例，并通过文献综述讨论可能的潜在机制。虽然肾切除或原发性肿瘤治疗后转移性RCC出现消退已有报道，但自发消退很少见。推测的潜在原因包括肿瘤坏死和免疫介导反应。在已确认的29例自发消退病例中，只有我们的病例仅在活检后发生。更好地了解RCC自发消退的病理生理学将改善其治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ac3/11570451/a5fb30cfb209/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ac3/11570451/867b9d2d63bd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ac3/11570451/8b07591151cd/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ac3/11570451/a5fb30cfb209/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ac3/11570451/867b9d2d63bd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ac3/11570451/8b07591151cd/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ac3/11570451/a5fb30cfb209/gr3.jpg

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Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer.肾切除术后联合干扰素α-2b与单独使用干扰素α-2b治疗转移性肾细胞癌的比较。
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