Huckaby Lauren V, Leshnower Bradley G
Division of Cardiac Surgery, Emory University Atlanta, GA.
US Cardiol. 2023 Sep 28;17:e14. doi: 10.15420/usc.2022.39. eCollection 2023.
Dilatation of the thoracic or abdominal aorta can progress to dissection or rupture with significant associated morbidity and mortality. Aortic disease remains a treatable contributor to mortality in the US and its burden is likely underestimated. Recent clinical studies have uncovered sex and gender distinctions in the epidemiology, pathophysiology, and outcomes of aortic disease. Despite this, there has been little progress in the application of these findings to clinical practice. Improved understanding of the sex-specific mechanisms of aortic disease may inform personalized indications for elective repair and thus reduce the morbidity of aortic catastrophe. The objective of this review is to summarize known clinical and biological sex differences in both thoracic and abdominal aortic disease and highlight promising areas for future investigation.
胸主动脉或腹主动脉扩张可进展为夹层或破裂，伴有显著的相关发病率和死亡率。在美国，主动脉疾病仍是导致死亡的一个可治疗因素，其负担可能被低估。最近的临床研究揭示了主动脉疾病在流行病学、病理生理学和预后方面存在性别差异。尽管如此，将这些发现应用于临床实践方面进展甚微。更好地理解主动脉疾病的性别特异性机制可能为选择性修复的个性化指征提供依据，从而降低主动脉灾难的发病率。本综述的目的是总结胸主动脉和腹主动脉疾病已知的临床和生物学性别差异，并突出未来研究的有前景领域。
