Urquhart Siri A, Kim Grace Y, Anderson Katelyn R, Chedid Victor G
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
Department of Dermatology, Mayo Clinic, Rochester, MN.
ACG Case Rep J. 2024 Nov 16;11(11):e01559. doi: 10.14309/crj.0000000000001559. eCollection 2024 Nov.
Orofacial granulomatosis (OFG) is a rare syndrome that can occur in association with Crohn's disease (CD). The electronic medical record was searched for "OFG" and "CD." A total of 297 patients were identified, and relevant data were abstracted. Five patients met inclusion criteria. Most (80%) had ileocolonic CD with nonstricturing/nonpenetrating phenotype. The most common treatments included intralesional corticosteroids (4 patients), oral corticosteroids (3 patients), and anti-TNF agents, specifically infliximab (3 patients). Intralesional corticosteroid administration was followed by partial response in 3 patients, but recurrences were common following initial injection. One patient had no response to topical or oral corticosteroids, antihistamines, or oral antibiotics, but partial response to intralesional corticosteroids and infliximab. None of the patients had complete response to any therapies directed at this condition. OFG may be characterized by partial response, often requiring long-term therapy. Additional investigations into novel treatments may improve future clinical outcomes.
口面部肉芽肿病（OFG）是一种可与克罗恩病（CD）相关联发生的罕见综合征。通过检索电子病历查找“OFG”和“CD”。共识别出297例患者，并提取了相关数据。5例患者符合纳入标准。大多数（80%）患有回结肠型CD，具有非狭窄/非穿透性表型。最常见的治疗方法包括病灶内注射皮质类固醇（4例患者）、口服皮质类固醇（3例患者）以及抗TNF药物，特别是英夫利昔单抗（3例患者）。3例患者在病灶内注射皮质类固醇后出现部分缓解，但初次注射后复发很常见。1例患者对局部或口服皮质类固醇、抗组胺药或口服抗生素均无反应，但对病灶内注射皮质类固醇和英夫利昔单抗有部分反应。没有患者对针对这种病症的任何治疗有完全缓解。OFG的特点可能是部分缓解，通常需要长期治疗。对新型治疗方法的进一步研究可能会改善未来的临床结果。
