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头颈部癌的动脉内化疗

Intra-arterial Chemotherapy for Head and Neck Cancer.

作者信息

Yoshida Daisuke

机构信息

Diagnostic Imaging Center, Sapporo Yamanoue Hospital, Japan.

出版信息

Interv Radiol (Higashimatsuyama). 2023 Jun 3;9(3):127-133. doi: 10.22575/interventionalradiology.2022-0042. eCollection 2024 Nov 1.

DOI:10.22575/interventionalradiology.2022-0042
PMID:39559816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11570212/
Abstract

Superselective intra-arterial chemoradiotherapy for head and neck cancer is a combination of intensive local delivery of anticancer drugs using microcatheters and external beam radiation. Unlike conventional chemoradiotherapy, it is highly effective in treating the primary tumor, but it cannot treat distant metastases. In the field of head and neck cancer, where quality of life is significantly impaired by curative surgery from a functional and cosmetic point of view, it is a useful treatment not only for unresectable cases but also for resectable advanced cancers, with the maxillary sinus being a particularly good indication. This treatment is expected to outperform conventional systemic chemotherapy and even comes close to the outcomes of radical surgery if the patient is carefully selected and the appropriate technique is used. Currently, a multicenter phase III clinical trial to evaluate the efficacy of this treatment for maxillary sinus cancer has been completed, and the results are being analyzed.

摘要

头颈部癌的超选择性动脉内放化疗是一种将使用微导管进行的抗癌药物局部强化给药与外照射放疗相结合的治疗方法。与传统放化疗不同，它在治疗原发性肿瘤方面非常有效，但无法治疗远处转移灶。在头颈部癌领域，从功能和美观角度来看，根治性手术会严重损害生活质量，这种治疗方法不仅对不可切除的病例有用，对可切除的晚期癌症也有用，上颌窦癌是特别好的适应证。如果仔细选择患者并使用适当的技术，这种治疗有望优于传统的全身化疗，甚至接近根治性手术的效果。目前，一项评估该治疗对上颌窦癌疗效的多中心III期临床试验已经完成，结果正在分析中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27f/11570212/205ad17c14e5/2432-0935-9-3-0127-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27f/11570212/552ec50d7a0b/2432-0935-9-3-0127-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27f/11570212/2c8f6fe30f12/2432-0935-9-3-0127-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27f/11570212/cbb4c3ecd194/2432-0935-9-3-0127-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27f/11570212/205ad17c14e5/2432-0935-9-3-0127-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27f/11570212/552ec50d7a0b/2432-0935-9-3-0127-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27f/11570212/2c8f6fe30f12/2432-0935-9-3-0127-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27f/11570212/cbb4c3ecd194/2432-0935-9-3-0127-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27f/11570212/205ad17c14e5/2432-0935-9-3-0127-g004.jpg

相似文献

1
Intra-arterial Chemotherapy for Head and Neck Cancer.头颈部癌的动脉内化疗
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2
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3
Salvage surgery improves the treatment outcome of patients with residual/recurrent maxillary sinus cancer after superselective intra-arterial cisplatin infusion with concomitant radiation therapy.挽救性手术可改善在超选择性动脉内输注顺铂并同步放疗后出现残留/复发性上颌窦癌患者的治疗效果。
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4
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The superselective intra-arterial infusion of cisplatin and concomitant radiotherapy (RADPLAT) is effective for metastatic lymph nodes in head and neck squamous cell carcinoma.顺铂超选择性动脉内灌注联合放射治疗（RADPLAT）对头颈部鳞状细胞癌转移性淋巴结有效。
Int J Clin Oncol. 2023 Sep;28(9):1121-1128. doi: 10.1007/s10147-023-02363-5. Epub 2023 Jun 8.
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High-dose superselective intra-arterial cisplatin and concomitant radiation (RADPLAT) for advanced head and neck cancer.高剂量超选择性动脉内顺铂与同步放疗（RADPLAT）治疗晚期头颈癌
Head Neck. 2004 Jun;26(6):485-93. doi: 10.1002/hed.20006.
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The efficacy of superselective intra-arterial infusion with concomitant radiotherapy for adenoid cystic carcinoma of the head and neck.超选择性动脉内灌注联合放疗对头颈部腺样囊性癌的疗效
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Intra-arterial chemotherapy less intensive than RADPLAT with concurrent radiotherapy for resectable advanced head and neck squamous cell carcinoma: a prospective study.对于可切除的晚期头颈部鳞状细胞癌，采用强度低于RADPLAT的动脉内化疗联合同期放疗：一项前瞻性研究。
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The incidence of late neck recurrence in N0 maxillary sinus squamous cell carcinomas after superselective intra-arterial chemoradiotherapy without prophylactic neck irradiation.未行预防性颈部放疗的N0期上颌窦鳞状细胞癌经超选择性动脉内放化疗后颈部迟发性复发的发生率
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Superselective intra-arterial cisplatin infusion and concomitant radiotherapy for maxillary sinus cancer.上颌窦癌的超选择性动脉内顺铂灌注化疗并同期放疗。
Br J Cancer. 2013 Dec 10;109(12):2980-6. doi: 10.1038/bjc.2013.663. Epub 2013 Nov 5.

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Intra-arterial chemoradiotherapy for head and neck cancer.头颈部癌的动脉内放化疗
Jpn J Clin Oncol. 2016 Jan;46(1):4-12. doi: 10.1093/jjco/hyv151. Epub 2015 Oct 20.
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Intra-arterial versus intravenous chemoradiation for advanced head and neck cancer: Results of a randomized phase 3 trial.头颈部晚期癌症的动脉内与静脉内放化疗比较：一项随机 3 期试验结果。
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