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盘多拉亭A减轻葡聚糖硫酸钠（DSS）诱导的结肠炎小鼠模型中的炎症和氧化应激。

Panduratin A mitigates inflammation and oxidative stress in DSS-induced colitis mice model.

作者信息

Alqudah Abdelrahim, Qnais Esam, Gammoh Omar, Bseiso Yousra, Wedyan Mohammed, Oqal Muna

机构信息

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan.

Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan.

出版信息

Future Sci OA. 2024 Dec;10(1):2428129. doi: 10.1080/20565623.2024.2428129. Epub 2024 Nov 19.

DOI:10.1080/20565623.2024.2428129
PMID:39559852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11581177/
Abstract

AIM

This study explored Panduratin A's protective effects against DSS-induced colitis in mice, focusing on reducing inflammation and oxidative stress in the colon.

METHODS

Mice were treated with dextran sodium sulfate (DSS) and Panduratin A (3, 6, 18 mg/kg), and changes in body weight, colon length, Disease Activity Index (DAI), histopathology, inflammation markers including tumor necrosis factor- α (TNF-α), Interleukin-1 β (IL-1β), Myeloperoxidase (MPO), and oxidative stress, Malondialdehyde (MDA) were evaluated.

RESULTS

Panduratin A significantly reversed DSS-induced symptoms, including body weight loss, colonic length shortening, and DAI increase, while reducing histopathological damage. It lowered inflammatory markers and oxidative stress, suppressed NF-κB activation, and enhanced Nrf2 and HO-1 expression.

CONCLUSION

Panduratin A shows promise as a colitis treatment, warranting further research for broader clinical application.

摘要

目的

本研究探讨了潘多拉丁A对葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎的保护作用，重点关注减轻结肠炎症和氧化应激。

方法

用葡聚糖硫酸钠（DSS）和潘多拉丁A（3、6、18毫克/千克）处理小鼠，评估体重、结肠长度、疾病活动指数（DAI）、组织病理学、包括肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、髓过氧化物酶（MPO）在内的炎症标志物以及氧化应激、丙二醛（MDA）的变化。

结果

潘多拉丁A显著逆转了DSS诱导的症状，包括体重减轻、结肠长度缩短和DAI升高，同时减少了组织病理学损伤。它降低了炎症标志物和氧化应激，抑制了NF-κB激活，并增强了Nrf2和HO-1表达。

结论

潘多拉丁A有望成为一种结肠炎治疗药物，值得进一步研究以实现更广泛的临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/8259109a5de4/IFSO_A_2428129_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/dce046423180/IFSO_A_2428129_UF0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/cd7d4cdda3cd/IFSO_A_2428129_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/78e5eaee72dc/IFSO_A_2428129_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/9226a9629723/IFSO_A_2428129_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/1c4002f87a5a/IFSO_A_2428129_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/8259109a5de4/IFSO_A_2428129_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/dce046423180/IFSO_A_2428129_UF0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/cd7d4cdda3cd/IFSO_A_2428129_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/78e5eaee72dc/IFSO_A_2428129_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/9226a9629723/IFSO_A_2428129_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/1c4002f87a5a/IFSO_A_2428129_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb9f/11581177/8259109a5de4/IFSO_A_2428129_F0005_B.jpg

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