Fuquan Zhang, Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, China,
J Prev Alzheimers Dis. 2024;11(6):1843-1848. doi: 10.14283/jpad.2024.113.
The preceding evidence indicates a close correlation between imbalances in the gut microbiome and Alzheimer's disease (AD), yet the direct causal relationship remains unclear. Our objective is to investigate this potential causal connection.
We obtained summary results from two significant genome-wide association studies (GWAS) on gut microbiota (the MibioGen consortium and the Dutch Microbiome Project), along with one GWAS summary result for AD. Using a two-sample Mendelian randomization (TSMR) analysis, we examined the potential causal effects of gut microbiota on AD.
Our TSMR analysis revealed that 16 gut bacterial taxa were linked to a reduced risk of AD. These included phylum Tenericutes, classes Bacilli and Clostridia along with its order Clostridiales, family Bacteroidaceae, genus Bacteroides, and species Bifidobacterium bifidum (OR: 0.8670.971, P ≤ 0.045). Conversely, the presence of 12 taxa correlated with an increased risk of AD. These comprised class Actinobacteria and its family Coriobacteriaceae, as well as class Betaproteobacteria, its order Burkholderiales, and its family Sutterellaceae (OR: 1.0421.140, P ≤ 0.035).
Our research uncovered evidence suggesting certain gut bacterial species might play a causal role in AD risk, providing a fresh angle for AD treatment strategies.
先前的证据表明，肠道微生物组的失衡与阿尔茨海默病（AD）之间存在密切关联，但直接的因果关系尚不清楚。我们的目的是研究这种潜在的因果关系。
我们从两项关于肠道微生物组的重要全基因组关联研究（GWAS）（MibioGen 联盟和荷兰微生物组计划）以及一项关于 AD 的 GWAS 汇总结果中获得了汇总结果。我们使用两样本孟德尔随机化（TSMR）分析来检查肠道微生物组对 AD 的潜在因果影响。
我们的 TSMR 分析表明，16 种肠道细菌与 AD 风险降低有关。这些包括门厚壁菌门、纲芽孢杆菌纲和梭菌纲及其目梭状芽孢杆菌目、科拟杆菌科、属拟杆菌属和种双歧双歧杆菌（OR：0.8670.971，P ≤ 0.045）。相反，12 种细菌与 AD 风险增加有关。这些包括放线菌纲及其科考氏菌科，以及β变形菌纲、目伯克霍尔德氏菌目和科萨特雷拉科（OR：1.0421.140，P ≤ 0.035）。
我们的研究发现了一些肠道细菌物种可能在 AD 风险中起因果作用的证据，为 AD 治疗策略提供了新的视角。
