Rea Reyes Ramiro Eduardo, Cody Karly A, Wilson Rachael E, Zetterberg Henrik, Chin Nathaniel A, Jonaitis Erin M, Bahr Melissa, Mandel Olivia, Wintlend Madilynn, Bendlin Barbara B, Okonkwo Ozioma C, Clark Lindsay R, Zammit Matt, Asthana Sanjay, Christian Bradley T, Betthauser Tobey J, Eisenmenger Laura, Langhough Rebecca E, Johnson Sterling C
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
Alzheimers Dement. 2025 Feb;21(2):e14406. doi: 10.1002/alz.14406. Epub 2024 Nov 19.
Patterns of signal from tau positron emission tomography (tau-PET) confined to the medial temporal lobe (MTL) or extended into the neocortex may be relevant for Alzheimer's disease (AD) research if they are linked to differential biomarker levels and cognitive decline.
Visual assessment of Tau-PET [F-18]florquinitau (FQT) exams from 728 initially non-demented older adults yielded four uptake groups: tau-negative (T-), MTL-only (T+), neocortex-only (T+), or both (T+). Mixed effects models assessed group differences in retrospective cognitive and plasma pTau217 trajectories.
T+ was the most common T+ group (n = 97; 93% A+) and exhibited the sharpest worsening in cognitive and pTau217 trajectories before tau PET.
The T+ category represents an intermediate to advanced stage of AD preceded by rising ptau217 and progressive cognitive decline. The pTau217 finding suggests that A+, T+ in MTL or neocortex could represent early AD stages, with a higher likelihood of progressing to more advanced stages.
Visual assessments of Tau-PET FQT revealed four distinct uptake groups: tau-negative (T-), MTL-only (T+), neocortex-only (T+), or both (T+). Amyloid positive participants in the T+ and T+ categories showed a retrospectively faster decline in their cognitive trajectories, and a sharper increase in pTau217 levels in plasma, compared to T-. The T+ group displayed sharper trajectories compared with the other Tau positive groups in both their cognitive scores and pTau217 plasma levels. Our results suggest that participants with Tau present in both MTL and neocortex represent an intermediate to advanced stage of AD, whereas participants with signals confined to either MTL or neocortex could represent earlier AD stages.
来自tau正电子发射断层扫描（tau-PET）的信号模式局限于内侧颞叶（MTL）或扩展至新皮质，如果它们与不同的生物标志物水平和认知衰退相关，可能对阿尔茨海默病（AD）研究具有重要意义。
对728名最初未患痴呆症的老年人的Tau-PET [F-18]氟喹尼tau（FQT）检查进行视觉评估，得出四个摄取组：tau阴性（T-）、仅MTL（T+）、仅新皮质（T+）或两者皆有（T+）。混合效应模型评估了回顾性认知和血浆pTau217轨迹的组间差异。
T+是最常见的T+组（n = 97；93% A+），并且在tau PET之前，其认知和pTau217轨迹的恶化最为明显。
T+类别代表AD的中级至高级阶段，在此之前pTau217升高且认知逐渐衰退。pTau217的研究结果表明，A+、MTL或新皮质中的T+可能代表AD的早期阶段，进展为更高级阶段的可能性更高。
对Tau-PET FQT的视觉评估揭示了四个不同的摄取组：tau阴性（T-）、仅MTL（T+）、仅新皮质（T+）或两者皆有（T+）。与T-相比，T+和T+类别中的淀粉样蛋白阳性参与者在回顾性认知轨迹上下降更快，血浆中pTau217水平升高更明显。与其他Tau阳性组相比，T+组在认知得分和血浆pTau217水平方面的轨迹变化更为明显。我们的研究结果表明，MTL和新皮质中均存在Tau的参与者代表AD的中级至高级阶段，而信号局限于MTL或新皮质的参与者可能代表AD的早期阶段。
