HPA轴的激活并不能解释2型糖尿病患者对GLP-1受体激动剂治疗无反应的原因。

Activation of the HPA Axis Does Not Explain Nonresponsiveness to GLP-1R Agonist Treatment in Individuals With Type 2 Diabetes.

作者信息

Tokgöz Sevilay, Boss Marti, Jansen Theodorus J P, Meijer Rick, Frielink Cathelijne, van Bon Arianne C, Tack Cees J, de Galan Bastiaan E, Gotthardt Martin

机构信息

Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands.

Netherlands Heart Institute, Utrecht, the Netherlands.

出版信息

Diabetes. 2025 Feb 1;74(2):212-222. doi: 10.2337/db24-0463.

It is unclear why some individuals with type 2 diabetes are unresponsive to treatment with glucagon-like peptide 1 receptor (GLP-1R) agonists, but hypothalamic-pituitary-adrenal (HPA) axis activation could play a role. We used [68Ga]Ga-NODAGA-exendin-4 positron emission tomography/computed tomography to compare pituitary GLP-1R expression between responders and nonresponders to treatment with GLP-1R agonists. Pituitary GLP-1R expression and HPA axis activation did not differ between responders and nonresponders to GLP-1R agonist treatment. In addition, pituitary radiolabeled exendin uptake was markedly higher in men than in women. Further study is required to explain treatment differences and understand sex differences in pituitary radiolabeled exendin uptake.