Ho J L, Klempner M S
Diagn Microbiol Infect Dis. 1986 Feb;4(2):133-8. doi: 10.1016/0732-8893(86)90147-1.
In a study of antibiotic combinations of clindamycin with rifampin, oxacillin, or vancomycin using the time kill-curve method, the combination of clindamycin and rifampin were sometimes synergistic (5 of 15 times), otherwise indifferent and always enhanced killing of fifteen tested Staphylococcus aureus isolates. In contrast, vancomycin and clindamycin or oxacillin and clindamycin were either indifferent or antagonistic (approximately 50%). Vancomycin alone, however, was generally as effective as the combinations of clindamycin and rifampin.
在一项使用时间杀菌曲线法研究克林霉素与利福平、苯唑西林或万古霉素抗生素组合的实验中，克林霉素和利福平的组合有时具有协同作用（15次中有5次），否则无明显作用，且总能增强对15株测试金黄色葡萄球菌分离株的杀灭效果。相比之下，万古霉素与克林霉素或苯唑西林与克林霉素的组合要么无明显作用，要么具有拮抗作用（约50%）。然而，单独使用万古霉素通常与克林霉素和利福平的组合效果相当。
