Marino Giuseppe, Marchetta Liliana, Negri Serena, Testa Filippo, Lugotti Daniele, Cavallo Giulia, Grassi Tommaso, Jaconi Marta, De Ponti Elena, Bonazzi Maria Cristina, Landoni Fabio, Fruscio Robert
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
UO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Gynecol Oncol. 2025 Jan;192:89-93. doi: 10.1016/j.ygyno.2024.11.007. Epub 2024 Nov 18.
Granulosa cell tumors (GCTs) are rare neoplasia that account for less than 5 % of all the ovarian tumors. Juvenile GCT histotype is generally observed in adolescent and young women, representing a very rare disease, so only a paucity of data are present in literature. The aim of this study is to analyse the oncologic and fertility outcome in our case series of juvenile GCTs.
Clinicopathological data were retrospectively collected and analysed from a cohort of 30 patients ovarian juvenile GCTs treated at IRCCS San Gerardo dei Tintori Hospital, Monza, between 1980 and 2024.
The median age of disease onset was 21.5. Among patients enrolled in the study, 80.0 % (24/30) were stage I (16/26, 1/26 and 7/26 of stage IA, IB and IC, respectively), 6.7 % (2/30) were stage II and 13.3 % stage III (4/30). In 86.7 % (26/30) of patients, a fertility-sparing surgery was carried out, while 13.3.% (4/30) of patients underwent radical surgery. Adjuvant chemotherapy was administered in 20.0 % (6/30) of cases, while 80.0 % (24/30) were followed only with surveillance. Three patients in thirty (10.0 %) relapsed and died of disease despite multi-therapeutic approaches. All of them had advanced stages of disease at time of diagnosis.
Juvenile GCT appears to have a good prognosis at stage I disease. However, advanced stage represents a hard challenge for clinicians, showing a high rate of relapse and mortality.
颗粒细胞瘤（GCTs）是一种罕见的肿瘤，占所有卵巢肿瘤的比例不到5%。青少年型颗粒细胞瘤组织学类型通常见于青少年和年轻女性，是一种非常罕见的疾病，因此文献中仅有少量数据。本研究的目的是分析我们的青少年颗粒细胞瘤病例系列的肿瘤学和生育结局。
回顾性收集并分析了1980年至2024年期间在蒙扎的IRCCS圣杰拉尔多·德伊廷托里医院接受治疗的30例卵巢青少年颗粒细胞瘤患者的临床病理数据。
疾病发病的中位年龄为21.5岁。在纳入研究的患者中，80.0%（24/30）为I期（IA期、IB期和IC期分别为16/26、1/26和7/26），6.7%（2/30）为II期，13.3%为III期（4/30）。86.7%（26/30）的患者接受了保留生育功能的手术，而13.3%（4/30）的患者接受了根治性手术。20.0%（6/30）的病例接受了辅助化疗，而80.0%（24/30）仅接受观察随访。尽管采取了多种治疗方法，30例患者中有3例（10.0%）复发并死于疾病。他们在诊断时均处于疾病晚期。
青少年颗粒细胞瘤I期疾病似乎预后良好。然而，晚期对临床医生来说是一个严峻的挑战，显示出高复发率和死亡率。
