卵巢幼年型颗粒细胞瘤保留生育功能手术的结局。
Outcomes of fertility-sparing surgery in ovarian juvenile granulosa cell tumor.
机构信息
Department of Gynecology Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Int J Gynecol Cancer. 2019 May;29(4):787-791. doi: 10.1136/ijgc-2018-000083. Epub 2019 Feb 6.
OBJECTIVE
To analyze the clinical characteristics, diagnosis, and treatment of ovarian juvenile granulosa cell tumor.
METHODS
The clinical and pathological data of six patients with ovarian juvenile granulosa cell tumor was collected.
RESULTS
The mean age of disease onset was 20.5 years (range 12 to 33). All six patients had an adnexal mass located laterally in the pelvis, and two developed ascites. All patients had fertility-sparing surgery with complete staging. The mean size of the tumors was 15.3 cm (range 5 to 35). Ovarian sex cord stromal tumors were diagnosed or highly suspected from the frozen sections for all patients. Five patients received three to six courses of postoperative adjuvant chemotherapy, with three receiving a bleomycin/etoposide/cisplatin regimen and two receiving a paclitaxel/carboplatin regimen. The five stage I patients had no recurrence with 52 to 155 months of follow-up. The patient with stage IIIB disease had a recurrence 55 months' later and underwent reoperation and chemotherapy. This patient remained disease-free 30 months after the reoperation.
CONCLUSIONS
Fertility-sparing surgery is the treatment of choice for ovarian juvenile granulosa cell tumor and the overall prognosis is good.
目的
分析卵巢幼年型颗粒细胞瘤的临床特点、诊断及治疗。
方法
收集了 6 例卵巢幼年型颗粒细胞瘤患者的临床和病理资料。
结果
发病年龄平均为 20.5 岁（12～33 岁）。6 例患者均为盆腔外侧附件包块，其中 2 例伴有腹水。所有患者均接受保留生育功能的全面分期手术，肿瘤平均大小为 15.3cm（5～35cm）。所有患者的冰冻切片均诊断或高度怀疑卵巢性索间质肿瘤。5 例患者接受了 3～6 个疗程的术后辅助化疗，其中 3 例接受博来霉素/依托泊苷/顺铂方案，2 例接受紫杉醇/卡铂方案。5 例Ⅰ期患者随访 52～155 个月无复发。1 例Ⅲ期患者 55 个月后复发，行再次手术及化疗，再次手术后 30 个月无疾病进展。
结论
保留生育功能的手术是卵巢幼年型颗粒细胞瘤的治疗选择，总体预后良好。
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