Yeo Yong-Hao, San Boon-Jian, Ahmad Ela, Tan Min-Choon, Sin Yuh-Miin, Jani Milena, Bloomingdale Richard J
Department of Internal Medicine/ Pediatrics, William Beaumont University Hospital, Royal Oak, MI, USA.
AIMST University, Malaysia.
Prev Med. 2025 Jan;190:108179. doi: 10.1016/j.ypmed.2024.108179. Epub 2024 Nov 17.
Our study aimed to assess the heart failure/cardiomyopathy-related population-level mortality trends among patients with obesity in the United States and disparities across demographics.
We queried the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database among adults aged ≥25 from 1999 to 2019. Heart failure/cardiomyopathy were listed as the main causes of death, with obesity as a contributing cause. We calculated age-adjusted mortality rates (AAMR) per 100,000 individuals and estimated the average annual percent change (AAPC). We also evaluated the social vulnerability of United States counties (2014-2018).
There were 29,334 deaths related to heart failure/cardiomyopathy among patients with comorbid obesity. The overall AAMR increased from 0.41 in 1999 to 0.94 in 2019, with an AAPC of 3.78 (95 % CI, 3.41-4.14). The crude mortality rate increase for heart failure/cardiomyopathy was greater in individuals with comorbid obesity than in those without. Males had a higher AAMR than females (0.78 vs 0.55). African Americans also had higher AAMR than Whites (1.35 vs 0.62). The AAMR was higher in rural areas than in urban regions (0.76 vs 0.66). The overall AAMR was higher in counties with social vulnerability index-Quartile 4 (SVI-Q4) (most vulnerable) (1.08) compared to SVI-Q1 (least vulnerable) (0.63) with a risk ratio of 1.71 (95 % CI: 1.61-1.83).
Heart failure/cardiomyopathy mortality in individuals with comorbid obesity was rising. Males, African Americans, and individuals from rural regions had higher AAMR than their counterparts.
我们的研究旨在评估美国肥胖患者中心力衰竭/心肌病相关的人群水平死亡率趋势以及不同人口统计学特征之间的差异。
我们查询了疾病控制与预防中心1999年至2019年年龄≥25岁成年人的广泛在线流行病学研究数据库。心力衰竭/心肌病被列为主要死因，肥胖作为一个促成因素。我们计算了每10万人的年龄调整死亡率（AAMR），并估计了平均年度百分比变化（AAPC）。我们还评估了美国各县（2014 - 2018年）的社会脆弱性。
合并肥胖的患者中有29334例死亡与心力衰竭/心肌病相关。总体AAMR从1999年的0.41增加到2019年的0.94，AAPC为3.78（95%CI，3.41 - 4.14）。合并肥胖的个体中，心力衰竭/心肌病的粗死亡率增加幅度大于无肥胖者。男性的AAMR高于女性（0.78对0.55）。非裔美国人的AAMR也高于白人（1.35对0.62）。农村地区的AAMR高于城市地区（0.76对0.66）。社会脆弱性指数处于四分位数4（SVI - Q4）（最脆弱）的县的总体AAMR（1.08）高于SVI - Q1（最不脆弱）的县（0.63），风险比为1.71（95%CI：1.61 - 1.83）。
合并肥胖个体的心力衰竭/心肌病死亡率在上升。男性、非裔美国人和农村地区的个体的AAMR高于其对应人群。
