Karami Yousof, Ehtiati Sajad, Ghasemi Hassan, Rafiee Maedeh, Zamani Sani Maryam, Hosseini Seyed Edris, Moradi Kazerouni Hossein, Movahedpour Ahmad, Aiiashi Saleh, Khatami Seyyed Hossein
Department of Clinical Science, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Chim Acta. 2025 Jan 30;566:120041. doi: 10.1016/j.cca.2024.120041. Epub 2024 Nov 17.
Brain cancer remains a formidable challenge with limited treatment options. Non-coding RNAs (ncRNAs) have emerged as promising biomarkers due to their dysregulation in tumorigenesis. This review explores the potential of biosensors for early detection of brain cancer by targeting ncRNAs. We discuss the classification and functions of ncRNAs, emphasizing their involvement in key cancer-related processes. Additionally, we delve into recent advancements in biosensor technology, focusing on their ability to accurately detect specific ncRNA biomarkers associated with brain cancer. Our findings underscore the potential of biosensors to revolutionize brain cancer diagnosis, enabling personalized medicine and improving patient outcomes. Future research should focus on refining biosensor technology and expanding their clinical application.
脑癌仍然是一个严峻的挑战，治疗选择有限。非编码RNA（ncRNAs）由于在肿瘤发生过程中的失调而成为有前途的生物标志物。本综述探讨了通过靶向ncRNAs的生物传感器早期检测脑癌的潜力。我们讨论了ncRNAs的分类和功能，强调了它们在关键癌症相关过程中的作用。此外，我们深入研究了生物传感器技术的最新进展，重点关注其准确检测与脑癌相关的特定ncRNA生物标志物的能力。我们的研究结果强调了生物传感器在彻底改变脑癌诊断方面的潜力，实现个性化医疗并改善患者预后。未来的研究应专注于改进生物传感器技术并扩大其临床应用。
