Department of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang Province, China.
Department of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang Province, China; Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Brain Res Bull. 2024 Dec;219:111134. doi: 10.1016/j.brainresbull.2024.111134. Epub 2024 Nov 17.
Cognitive dysfunction is one of the common comorbidities of epilepsy. More than 60 % of epilepsy patients may experience impairment in learning, memory, attention, and executive control. At present, it can only control the symptoms of seizures, and there is no specific treatment for cognitive impairment. Deep brain stimulation (DBS) has been used to treat intractable epilepsy, with proven safety. Recently data suggests that DBS can not only improve the seizure control, but also improved cognitive function. This review summarizes the effects of DBS on cognitive impairment in epilepsy, including the current status and application of DBS, the influence of different DBS targets on brain of DBS on cognitive impairment in epilepsy, the possible mechanisms of DBS on cognitive impairment and its future prospects. It provides a theoretical basis for its further clinical application in epilepsy patients with cognitive dysfunction.
认知功能障碍是癫痫的常见共病之一。超过 60%的癫痫患者可能会出现学习、记忆、注意力和执行控制方面的损害。目前，它只能控制癫痫发作的症状，而对于认知障碍没有特定的治疗方法。深部脑刺激 (DBS) 已被用于治疗难治性癫痫，其安全性已得到证实。最近的数据表明，DBS 不仅可以改善癫痫发作的控制，还可以改善认知功能。这篇综述总结了 DBS 对癫痫认知障碍的影响，包括 DBS 的现状和应用、不同 DBS 靶点对 DBS 对癫痫认知障碍的影响、DBS 对认知障碍的可能机制及其未来前景。它为其在癫痫伴认知功能障碍患者中的进一步临床应用提供了理论依据。
