Xia Luyao, Yuan Lian, Du Xiang-Dong, Wang Dongmei, Wang Jiesi, Xu Hang, Huo Lijuan, Tian Yang, Dai Qilong, Wei Shuochi, Wang Wenjia, Trihn Tammy H, Alnatour Omar I, Chen Dachun, Xiu Meihong, Wang Li, Yang Mi, Zhang Xiang Yang
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Schizophr Res. 2020 Jan;215:105-112. doi: 10.1016/j.schres.2019.11.012. Epub 2019 Nov 25.
Cognitive impairment is a core symptom of schizophrenia (SCZ); however, its pathophysiological mechanisms remain unclear. The sensory gating (SG) deficits reflected by P50 inhibition are recurring in SCZ, and this inhibition may be related to the cognitive deficits seen in these individuals. This study aimed to investigate the relationship between P50 inhibition and cognitive dysfunction in SCZ, which has not been fully investigated up to this point.
A total of 270 individuals with chronic SCZ and 116 healthy controls were enrolled in the study. Psychopathology of SCZ was rated by the positive and negative syndrome scale (PANSS), while cognitive function and P50 inhibition of subjects were assessed by the MATRICS Consensus Cognitive Battery (MCCB) and the electroencephalography system.
The MCCB total and its 10 index scores were significantly lower in patients than those in healthy controls (all p < 0.001). SCZ patients had a lower amplitude of S1, and higher P50 ratio than healthy controls (both p < 0.01). However, there were no significant correlations between the P50 ratio and any of the PANSS total and its subscale scores in SCZ patients (all p > 0.05). Moreover, no correlation was found between the P50 components and the MCCB scores (all p > 0.05).
Our findings suggest that the P50 inhibition deficits occur in Chinese individuals with SCZ, which may not be associated with their clinical symptoms and cognitive impairment.
认知障碍是精神分裂症（SCZ）的核心症状；然而，其病理生理机制仍不清楚。P50抑制所反映的感觉门控（SG）缺陷在SCZ中反复出现，且这种抑制可能与这些个体中出现的认知缺陷有关。本研究旨在探讨P50抑制与SCZ认知功能障碍之间的关系，这一点此前尚未得到充分研究。
本研究共纳入270例慢性SCZ患者和116名健康对照者。采用阳性和阴性症状量表（PANSS）对SCZ的精神病理学进行评分，同时通过MATRICS共识认知成套测验（MCCB）和脑电图系统评估受试者的认知功能和P50抑制情况。
患者的MCCB总分及其10项指标得分均显著低于健康对照者（均p<0.001）。SCZ患者的S1波幅低于健康对照者，P50比率高于健康对照者（均p<0.01）。然而，SCZ患者的P50比率与PANSS总分及其任何子量表得分之间均无显著相关性（均p>0.05）。此外，未发现P50成分与MCCB得分之间存在相关性（均p>0.05）。
我们的研究结果表明，P50抑制缺陷存在于中国SCZ患者中，这可能与他们的临床症状和认知障碍无关。
