Zarębska-Michaluk Dorota, Rzymski Piotr, Kanecki Krzysztof, Tyszko Piotr, Lewtak Katarzyna, Goryński Paweł, Genowska Agnieszka, Parczewski Miłosz, Flisiak Robert
Department of Infectious Diseases and Allergology, Jan Kochanowski University, Kielce, Poland.
Department of Environmental Medicine, Poznan University of Medical Sciences, Poznań, Poland.
Sci Rep. 2024 Nov 19;14(1):28586. doi: 10.1038/s41598-024-80289-2.
Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) remains a significant public health challenge. This retrospective, population-based study assessed the trends in hospitalization rates among patients co-infected with HCV and HIV in Poland in 2012-2022, encompassing the COVID-19 pandemic and massive influx of war refugees from Ukraine, the demographics and clinical characteristics among hospitalized patients, including in-hospital case fatality rates. Most hospitalized patients were over 40 years old (mean ± SD: 41.7 ± 8.9 years) and were men (74%). The mean annual hospitalization rate was estimated at 1.33 per 10 and was three-fold lower in the pandemic period (mean 0.51 per 10) than in the pre-pandemic era (mean 1.63 per 10). In turn, the in-hospital case-fatality rates increased during the pandemic in men (from a mean of 1.83 to 3.93) but not in women (a mean of 1.53 in both periods). There was no significant increase in hospitalization rates in 2022, during which the significant inflow of war refugees in Ukraine occurred. The epidemiological situation of people (co)infected with HIV and HCV in Poland requires further monitoring, though it did not escalate in the studied period due to the influx of war refugees from Ukraine.
人类免疫缺陷病毒（HIV）与丙型肝炎病毒（HCV）合并感染仍然是一项重大的公共卫生挑战。这项基于人群的回顾性研究评估了2012年至2022年波兰HIV与HCV合并感染患者的住院率趋势，涵盖了新冠疫情以及来自乌克兰的大量战争难民涌入的情况，还包括住院患者的人口统计学特征和临床特征，以及住院病死率。大多数住院患者年龄超过40岁（平均±标准差：41.7±8.9岁），且为男性（74%）。年平均住院率估计为每10人中有1.33人，在疫情期间（平均每10人中有0.51人）比疫情前时期（平均每10人中有1.63人）低三倍。相应地，男性在疫情期间的住院病死率有所上升（从平均1.83升至3.93），但女性没有（两个时期平均均为1.53）。2022年，在乌克兰战争难民大量涌入期间，住院率没有显著增加。波兰HIV和HCV（合并）感染人群的流行病学情况需要进一步监测，不过在研究期间，由于来自乌克兰的战争难民涌入，情况并未升级。
