Health Care Division, Health and Counseling Center, Osaka University, 1-17 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.
Sci Rep. 2024 Nov 19;14(1):28629. doi: 10.1038/s41598-024-79534-5.
Since sarcopenic obesity (SO) impacts negatively on our health, early detection of SO is essential. However, prevalence of SO in an apparently healthy population has not been well examined. This study aimed to elucidate the prevalence and related factors of SO in middle-aged women, and to investigate useful diagnostic criteria for SO. Body component analyses were conducted on 432 female Osaka University employees aged 30-59 during their health checkups. Healthy (H) and SO groups were defined using cutoff values of 5.7 kg/m for skeletal muscle mass index and 30% for percent body fat. Serum myostatin and insulin levels were additionally measured. Among 432 participants, the prevalence of SO was 6.3%. Grip strength (P < 0.0001) was lower and triglyceride (P = 0.0004) and low-density lipoprotein cholesterol (P = 0.0105) levels, and Homeostatic Model Assessment of Insulin Resistance (P = 0.0262) were higher in the SO group than in the H group. Serum myostatin levels in the SO group were lower than in the H group (3,107 pg/mL vs. 3,957 pg/mL, P = 0.0003). Myostatin levels may be suppressed in individuals with SO without any pre-existing conditions. Our diagnostic criteria for SO could reveal the risks for metabolic-related diseases and may be useful for the early detection of SO.
由于肌少症合并肥胖（SO）对健康有负面影响，因此早期发现 SO 至关重要。然而，目前尚未充分研究在健康人群中 SO 的流行情况。本研究旨在阐明中年女性中 SO 的流行情况及其相关因素，并探讨 SO 的有用诊断标准。在健康检查期间，对大阪大学的 432 名 30-59 岁的女性员工进行了身体成分分析。使用骨骼肌质量指数的 5.7 kg/m2 和体脂肪百分比的 30%作为截断值，将健康（H）和 SO 组定义为。此外，还测量了血清肌肉生长抑制素和胰岛素水平。在 432 名参与者中，SO 的患病率为 6.3%。与 H 组相比，SO 组的握力（P<0.0001）较低，甘油三酯（P=0.0004）和低密度脂蛋白胆固醇（P=0.0105）水平较高，胰岛素抵抗的稳态模型评估（P=0.0262）较高。SO 组的血清肌肉生长抑制素水平低于 H 组（3107 pg/mL 比 3957 pg/mL，P=0.0003）。可能是没有任何预先存在的疾病的情况下，SO 个体的肌肉生长抑制素水平被抑制。我们的 SO 诊断标准可以揭示与代谢相关疾病的风险，并且可能有助于早期发现 SO。
