Laboratory of Food Biochemistry and Natural Substances, University of Sciences, Techniques and Technologies of Bamako (USTTB), BP: E 3206, Bamako, Mali.
Laboratory of Natural Substances Chemistry, University of Sciences, Techniques and Technologies of Bamako (USTTB), BP: E 3206, Bamako, Mali.
Sci Rep. 2024 Nov 19;14(1):28656. doi: 10.1038/s41598-024-78405-3.
Acridocarpus monodii Arène & Jaeger is an endemic plant species to the ''Dogon Country'' in Mali. This species is highly popular in Dogon ethnic groups, but no scientific data on its medicinal and biochemical properties are available in Mali. This work aimed to list its medicinal uses and assess its phytochemical composition and antioxidant power. An ethnobotanical investigation based on semi structured questionnaire was used to identify the traditional uses of A. monodii among the local population in three villages (Ireli, Youdiou and Yon-biré) inside ''Dogon country'' in Mali. The phytochemical composition was determined using qualitative tests, while the antioxidant potency was performed using 2,2-diphenyl-1-picryhydazyl (DPPH) and phosphomolybdate (TAC) tests. A total of 45 people were interviewed, the majority of whom were male (82.20%) and over 52 years of age. A. monodii is used to treat a dozen pathologies or diseases, dominated by malaria (71.10%), yellow fever (24.40%) and dysuria (20%). Although, all parts of this species are used to treat these pathologies, leaves (88.90%) were the most coveted followed by roots (37.80%). The use of these parts was significantly (p = 0.016 < 0.05) associated with the educational levels of the respondents (77.70%), who coveted primarily roots and barks, and thus constituted a threat to the species. These medicinal recipes derived from these organs were mostly prepared as decoctions, before being administered by oral (100%) or bath (82.20%) routes. Extracts of A. monodii were found to contain various biocompounds, especially a high quantity of flavonoids and polyphenols and demonstrated increased in vitro antioxidant inhibitory effects. The decoction extracts showed the highest content of phenolic compounds (109.82 ± 2.36 mg GAE/g). The strongest activity for the DPPH free radical scavenging were recorded by the decoction with IC = 107.41 ± 4.25 µg/mL and the hydroethanolic macerate with 107.31 ± 9.28 µg/mL. But, based on the results from of TAC test, the antioxidant capacity was higher for the hydroethanolic macerate 42.85 ± 2.59 mg EQ/g than those of the decoction 19.27 ± 0.93 mg EQ/g. This is the first scientific report on the therapeutic use of A. monodii within ''Dogon country'' in Mali. This work highlights its medicinal, phytochemical and biochemical properties and therefore contributes to its improved valorization. These results demonstrated that A. monodii is a promising species for the discovery of novel medicines.
阿克里多卡普斯·莫诺迪（Acridocarpus monodii Arène & Jaeger）是马里多贡地区特有的植物物种。这种物种在多贡族群中非常受欢迎，但在马里没有关于其药用和生化特性的科学数据。这项工作旨在列出其药用用途，并评估其植物化学成分和抗氧化能力。
我们使用半结构式问卷进行了一项民族植物学调查，以确定马里多贡地区三个村庄（Ireli、Youdiou 和 Yon-biré）当地居民对 A. monodii 的传统用途。使用定性测试确定植物化学成分，使用 2,2-二苯基-1-苦基肼（DPPH）和磷钼酸盐（TAC）测试评估抗氧化能力。共有 45 人接受了采访，其中大多数是男性（82.20%），年龄超过 52 岁。A. monodii 用于治疗十几种疾病或病症，其中以疟疾（71.10%）、黄热病（24.40%）和尿痛（20%）为主。尽管该物种的所有部位都可用于治疗这些疾病，但叶片（88.90%）是最受欢迎的，其次是根（37.80%）。这些部位的使用与受访者的教育水平（p=0.016<0.05）显著相关，受访者主要渴望使用根和树皮，因此对物种构成了威胁。这些来自这些器官的药用配方主要以汤剂形式制备，然后通过口服（100%）或浴疗（82.20%）途径给药。A. monodii 的提取物被发现含有各种生物化合物，特别是含有大量的类黄酮和多酚，并且表现出体外抗氧化抑制作用的增加。汤剂提取物显示出最高含量的酚类化合物（109.82±2.36 mg GAE/g）。DPPH 自由基清除能力最强的是汤剂提取物，IC=107.41±4.25μg/mL，而水醇浸膏的 IC=107.31±9.28μg/mL。但是，根据 TAC 测试的结果，水醇浸膏的抗氧化能力（42.85±2.59 mg EQ/g）高于汤剂提取物（19.27±0.93 mg EQ/g）。这是马里多贡地区 A. monodii 治疗用途的首次科学报告。这项工作强调了它的药用、植物化学和生物化学特性，因此有助于提高其价值。这些结果表明，A. monodii 是一种有前途的用于发现新型药物的物种。
