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SRP9/SRP14 在调节 Alu RNA 中的作用。

The role of SRP9/SRP14 in regulating Alu RNA.

机构信息

Department of Chemistry, University of Manitoba, Winnipeg, MB, Canada.

出版信息

RNA Biol. 2024 Jan;21(1):1-12. doi: 10.1080/15476286.2024.2430817. Epub 2024 Nov 19.

DOI:10.1080/15476286.2024.2430817
PMID:39563162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11581171/
Abstract

SRP9/SRP14 is a protein heterodimer that plays a critical role in the signal recognition particle through its interaction with the scaffolding signal recognition particle RNA (7SL). SRP9/SRP14 binding to 7SL is mediated through a conserved structural motif that is shared with the primate-specific Alu RNA. Alu RNA are transcription products of Alu elements, a retroelement that comprises ~10% of the human genome. Alu RNA are involved in myriad biological processes and are dysregulated in several human disease states. This review focuses on the roles SRP9/SRP14 has in regulating Alu RNA diversification, maturation, and function. The diverse mechanisms through which SRP9/SRP14 regulates Alu RNA exemplify the breadth of protein-mediated regulation of non-coding RNA.

摘要

SRP9/SRP14 是一种蛋白质异二聚体，通过与支架信号识别颗粒 RNA（7SL）相互作用，在信号识别颗粒中发挥关键作用。SRP9/SRP14 与 7SL 的结合是通过与灵长类特异性 Alu RNA 共享的保守结构基序介导的。Alu RNA 是 Alu 元件的转录产物，Alu 元件是人类基因组的约 10%。Alu RNA 参与了多种生物学过程，并在几种人类疾病状态中失调。本综述重点介绍了 SRP9/SRP14 在调节 Alu RNA 多样化、成熟和功能中的作用。SRP9/SRP14 调节 Alu RNA 的多种机制体现了蛋白质对非编码 RNA 调节的广泛性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136b/11581171/c81f98d824f1/KRNB_A_2430817_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136b/11581171/d9629bba9b8e/KRNB_A_2430817_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136b/11581171/2e377526636a/KRNB_A_2430817_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136b/11581171/c81f98d824f1/KRNB_A_2430817_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136b/11581171/d9629bba9b8e/KRNB_A_2430817_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136b/11581171/2e377526636a/KRNB_A_2430817_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/136b/11581171/c81f98d824f1/KRNB_A_2430817_F0003_OC.jpg

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Cryo-EM structure of SRP68/72 reveals an extended dimerization domain with RNA-binding activity.冷冻电镜结构显示 SRP68/72 具有扩展的二聚化结构域和 RNA 结合活性。
Nucleic Acids Res. 2024 May 22;52(9):5285-5300. doi: 10.1093/nar/gkae107.
3
Alu RNA fold links splicing with signal recognition particle proteins.Alu RNA 折叠将剪接与信号识别颗粒蛋白联系起来。
Nucleic Acids Res. 2023 Aug 25;51(15):8199-8216. doi: 10.1093/nar/gkad500.
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Chromatin-interacting RNA-binding proteins regulate transcription.染色质相互作用 RNA 结合蛋白调节转录。
Trends Cell Biol. 2023 Aug;33(8):625-629. doi: 10.1016/j.tcb.2023.05.006. Epub 2023 Jun 1.
5
Nuclear SRP9/SRP14 heterodimer transcriptionally regulates 7SL and BC200 RNA expression.核 SRP9/SRP14 异二聚体转录调控 7SL 和 BC200 RNA 的表达。
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Alu RNA and their roles in human disease states.Alu RNA 及其在人类疾病状态中的作用。
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