Department of Internal Medicine, Division of Rheumatology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
Department of Urology, Ministry of Health Karasu State Hospital, Karasu/Sakarya, 54500, Turkey.
BMC Urol. 2024 Nov 20;24(1):257. doi: 10.1186/s12894-024-01650-1.
To evaluate the effect of neuropathic pain on lower urinary tract symptoms (LUTS) scores in patients with primary Sjögren's syndrome (pSS).
Seventy-two patients diagnosed with pSS were included in the study. The patients with pSS were divided into two groups according to the presence/absence of neuropathic pain. The Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) questionnaire was recorded assess neuropathic pain. LUTS was evaluated using the International Prostate Symptom Score (IPSS), International Incontinence Consultation Questionnaire Short Form (ICIQ-SF) and Overactive Bladder Questionnaire (OAB-V8).
The mean age of the patients was 52.4 ± 11.2 years. Neuropathic pain was recorded in 21 (29.2%) patients. Among the patients, the number of patients with mild symptoms was recorded as 41 (56.9%), moderate symptoms in 25 (34.7%), and severe symptoms in 6 (8.3%) according to IPSS. IPSS and IPSS voiding subscores were statistically significantly higher in patients with neuropathic pain than non-neuropathic pain group (p = 0.035; p = 0.001, respectively). Although ICIQ-SF, OAB-V8 and IPSS storage subscores were found to be higher in patients with neuropathic pain group, there was no statistically significant difference between the groups (p = 0.299; p = 0.283; p = 0.237, respectively).
Neuropathic pain concomitant with PSS patients may negatively affect bladder voiding functions.
评估原发性干燥综合征（pSS）患者的神经病理性疼痛对下尿路症状（LUTS）评分的影响。
本研究纳入了 72 例确诊为 pSS 的患者。根据是否存在神经病理性疼痛，将 pSS 患者分为两组。采用 Leeds 评估神经病理性症状和体征问卷（LANSS）记录评估神经病理性疼痛。采用国际前列腺症状评分（IPSS）、国际尿失禁咨询问卷简表（ICIQ-SF）和膀胱过度活动症问卷（OAB-V8）评估 LUTS。
患者的平均年龄为 52.4±11.2 岁。21 例（29.2%）患者存在神经病理性疼痛。根据 IPSS，患者中轻度症状的患者有 41 例（56.9%），中度症状的患者有 25 例（34.7%），重度症状的患者有 6 例（8.3%）。与无神经病理性疼痛组相比，有神经病理性疼痛组的 IPSS 和 IPSS 排尿症状评分更高（p=0.035；p=0.001）。虽然神经病理性疼痛组的 ICIQ-SF、OAB-V8 和 IPSS 存储症状评分较高，但两组间无统计学差异（p=0.299；p=0.283；p=0.237）。
pSS 患者伴发的神经病理性疼痛可能会对膀胱排空功能产生负面影响。
